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oai:figshare.com:article/34033323 2026-09-30T15:05:21Z category_4 category_272 category_873 category_39 category_734 portal_63 item_type_6 month_year_09_2026

Electrochemical One-Pot Diverse C(sp³)–X Bond (Including C–H, C–C, C–N, and C–O) Transformations and C(sp²)–H Acyloxylation of Alkylarenes Yu-Wei Jiang (11657352) Jia-Di Ren (25144566) Li-Xue Zhou (170731) Hui Gao (169623) Pei-Long Wang (792918) Biochemistry Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified unlike previous c c – n acetoxy radical mechanism 3 </ sub c – c pot diverse c sup >–</ sup c – acetoxy radical diverse c pot cleavage diverse substrates significantly increase prevents decarboxylation nontoxic solvents first time experimental results electrochemical one In this study, an electrochemical one-pot cleavage of diverse C(sp³)–X bonds and acyloxylation of C(sp²)–H were reported. Based on the experimental results, we discovered for the first time that NH₃ can strongly promote electrolyte dissolution and significantly increase the conductivity of a solution. Unlike previous C(sp²)–H acetoxylation reactions in which AcO^– functions as a nucleophile, this reaction undergoes an acetoxy radical mechanism and prevents decarboxylation of the acetoxy radical. This reaction is advantageous because it is transition-metal-free, external-oxidant-free, atom- and step-economical, and applicable to diverse substrates; additionally, it uses mild reaction conditions and green and nontoxic solvents. 2026-09-30T00:00:00Z Text Journal contribution 10.1021/acs.joc.6c01447.s001 https://figshare.com/articles/journal_contribution/Electrochemical_One-Pot_Diverse_C_sp_sup_3_sup_X_Bond_Including_C_H_C_C_C_N_and_C_O_Transformations_and_C_sp_sup_2_sup_H_Acyloxylation_of_Alkylarenes/34033323 CC BY-NC 4.0