2026-10-14T20:21:15Z
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2026-09-30T12:33:42Z
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<i>CircARID1A</i> promotes gastric cancer progression by targeting the <i>miR-147a</i>/SNAI2 signaling axis
Kai Guo (54091)
Xuemei Yan (422597)
Xing Liu (221084)
Yu Peng (144570)
Weitian Xu (317038)
Biophysics
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Gastric cancer
circARID1A
miR-147a
SNAI2
<p>Due to the late stage at which most gastric cancer patients are diagnosed, the prognosis is often poor. Current treatments have limited efficacy for advanced cases. This study delves into the involvement of <i>circARID1A</i> and the mechanisms behind its role in gastric cancer progression. GES-1 cell line and GC cell lines HGC-27, AGS, MKN45, and SNU-16 were cultured and subjected to various assays. RNA interference and overexpression techniques were used to modulate <i>circARID1A</i> and <i>miR-147a</i> levels <i>in vitro</i>, while xenograft tumor models in BALB/c nude mice were used to assess tumor growth <i>in vivo</i>. Cellular growth, migration, and invasion were assessed using CCK8, colony formation, and Transwell assays. Dual-luciferase reporter assays, qPCR and Western blot were utilized to investigate the interactions between <i>circARID1A</i>, <i>miR-147a</i>, and <i>SNAI2</i>. <i>CircARID1A</i> promotes GC cell proliferation, migration, and invasion by regulating the <i>miR-147a</i>/SNAI2 axis. <i>In vivo</i>, knockdown of <i>circARID1A</i> inhibits tumor growth in subcutaneous xenograft models.</p> <p></p><p>Suppression of <i>circARID1A</i> significantly inhibits gastric cancer cell proliferation, migration, and invasion.</p><p><i>miR-147a</i> directly targets and negatively regulates SNAI2 expression, inhibiting its oncogenic effects.</p><p>CircARID1A promotes cell proliferation, migration, and invasion in gastric cancer cells through the <i>miR-147a/SNAI2</i> signaling axis.</p><p></p> <p>Suppression of <i>circARID1A</i> significantly inhibits gastric cancer cell proliferation, migration, and invasion.</p> <p><i>miR-147a</i> directly targets and negatively regulates SNAI2 expression, inhibiting its oncogenic effects.</p> <p>CircARID1A promotes cell proliferation, migration, and invasion in gastric cancer cells through the <i>miR-147a/SNAI2</i> signaling axis.</p>
2026-09-30T12:33:42Z
Image
Figure
10.6084/m9.figshare.34032282.v1
https://figshare.com/articles/figure/_i_CircARID1A_i_promotes_gastric_cancer_progression_by_targeting_the_i_miR-147a_i_SNAI2_signaling_axis/34032282
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