2026-10-14T17:32:09Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34032113 2026-09-30T12:06:10Z category_4 category_21 category_873 category_62 category_69 category_106 portal_63 item_type_6 month_year_09_2026

The Convergent Synthetic Efforts toward Knightol and a Simplified Analog Learnmore Jeremia (24618323) Elise L. Bezold (19679211) Kate Bright (25143749) William M. Wuest (1308882) Biochemistry Biotechnology Chemical Sciences not elsewhere classified Marine Biology Inorganic Chemistry Science Policy exhibit antibiofilm activity eastern fragment accessible convergent total synthesis staphylococcus aureus </ stage transformations simplified analog selective epoxidation scalable cross macrocyclic framework key late gram scale enabled evaluation efforts toward We report our efforts toward the convergent total synthesis of the cembranoid diterpene (−)-knightol, a marine natural product reported to exhibit antibiofilm activity against <i>Staphylococcus aureus</i>, and a rationally designed aryl analog, <i>m</i>knightol. Our strategy was guided by a two-phase approach involving construction of the macrocyclic framework, followed by selective epoxidation and further diversification. Both targets were designed to arise from common western fragment building blocks and an eastern fragment accessible on a gram scale. A scalable cross-electrophile coupling provided efficient access to an advanced intermediate en route to the cyclophane and enabled evaluation of key late-stage transformations. 2026-09-30T00:00:00Z Text Journal contribution 10.1021/acs.joc.6c01838.s001 https://figshare.com/articles/journal_contribution/The_Convergent_Synthetic_Efforts_toward_Knightol_and_a_Simplified_Analog/34032113 CC BY-NC 4.0