2026-10-13T08:29:58Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34031641 2026-09-30T11:17:57Z category_4 category_19 category_21 category_873 category_46 category_734 portal_87 item_type_3 month_year_09_2026

Targeted UHPLC-QTOF-MS profiling coupled with anti-hyperglycaemic and nephroprotective evaluation of Acrostichum aureum L. aerial parts Anirbita Ghosh (25143508) Barun Das Gupta (25143511) Srijon Gayen (25143514) Suparna Ghosh (9698402) Monihar Pervin (25143517) Sandipan Jana (3702052) Ashok Kumar Balaraman (22282333) Pallab Kanti Haldar (14001898) Biochemistry Pharmacology Biotechnology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Acrostichum aureum L UHPLC-QTOF-MS phenolic compounds antihyperglycaemic activity Acrostichum aureum L. (Pteridaceae) is traditionally used to manage diabetes and murky urine. The study explores the phytoconstituents in A. aureum and evaluates the in vitro and in vivo bioactivity in anti-hyperglycaemic and nephroprotective assays. Targeted UHPLC-QTOF-MS analysis tentatively identified 9 compounds. In vitro enzyme inhibition assays demonstrated inhibition (IC50) of α-glucosidase (40.85 ± 0.6 μg/mL) and α-amylase (45.12 ± 0.28 μg/mL), comparable to acarbose (19.65 ± 0.58 μg/mL and 22.54 ± 0.28 μg/mL, respectively). The extract at 200 mg/kg and 400 mg/kg body weight reduced fasting blood glucose and HbA1c levels, along with improvements in serum creatinine, blood urea nitrogen, and urine microalbumin, in a high-fat diet–induced diabetic rat model treated with low-dose streptozotocin. Histopathological assessment showed reduced structural damage in the kidney, pancreas, and liver tissues. The study evaluates and links A. aureum phytoconstituents to the anti-hyperglycaemic and nephroprotective potential, providing a basis for further investigations to substantiate their potential as a source of bioactive natural products. 2026-09-30T11:17:57Z Dataset Dataset 10.6084/m9.figshare.34031641.v1 https://figshare.com/articles/dataset/Targeted_UHPLC-QTOF-MS_profiling_coupled_with_anti-hyperglycaemic_and_nephroprotective_evaluation_of_i_Acrostichum_aureum_i_L_aerial_parts/34031641 CC BY 4.0