2026-10-14T10:21:16Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34031608 2026-09-30T11:15:47Z category_4 category_146 category_8 category_19 category_272 category_873 portal_87 item_type_6 month_year_09_2026

Bioactive constituents from <i>Dioscorea bulbifera</i> L. rhizomes with antioxidant and α-glucosidase inhibitory properties Rong-Wei Kou (9941549) Abdulla Yusuf (21005305) Xin Liu (43569) Bing Xia (76986) Xin-Sheng Lu (23930353) Yang-Qing He (19258761) Biochemistry Space Science Microbiology Pharmacology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified antioxidant activity α-glucosidase inhibitory activity chemical constituents Dioscorea bulbifera L. <p>The chemical profile of the rhizomes of <i>Dioscorea bulbifera</i> L. was systematically investigated. As a result, nineteen known compounds were isolated and structurally characterised, comprising emodin (<b>1</b>), piceid (<b>2</b>), quercetin (<b>3</b>), physcion (<b>4</b>), kaempferol (<b>5</b>), caffeic acid methyl ester (<b>6</b>), resveratrol (<b>7</b>), 3,4,5-trihydroxybenzoic acid (<b>8</b>), resveratrol-2’’-<i>O</i>-galloylester (<b>9</b>), bisdemethoxycurcumin (<b>10</b>), resveratrol-<i>O</i>-<i>E</i>-phyllanthine (<b>11</b>), rhein (<b>12</b>), aloe-emodin (<b>13</b>), 5-methoxy-7-hydroxy-1(3H)-benzofuranone (<b>14</b>), questinol (<b>15</b>), vanillic acid (<b>16</b>), <i>β</i>-sitosterol (<b>17</b>), 3,4-dihydroxybenzoic acid (<b>18</b>), and diosgenin (<b>19</b>). All isolated compounds were evaluated for their α-glucosidase inhibitory and antioxidant activity. The results demonstrated that compounds <b>3</b>, <b>5</b>, <b>8</b>, <b>9</b>, and <b>18</b> exhibited antioxidant activity, with radical scavenging rates ranging from 84.19% to 97.73%, while <b>9</b>, <b>11</b>, <b>13</b>, and <b>15</b> showed α-glucosidase inhibitory effects, with IC₅₀ values ranging from 0.4556 to 1.3528 mg/mL. These findings indicate that the ethyl acetate fraction of <i>D. bulbifera</i> represents a promising source of multifunctional bioactive constituents and provides a chemical basis.</p> 2026-09-30T11:15:47Z Text Journal contribution 10.6084/m9.figshare.34031608.v1 https://figshare.com/articles/journal_contribution/Bioactive_constituents_from_i_Dioscorea_bulbifera_i_L_rhizomes_with_antioxidant_and_-glucosidase_inhibitory_properties/34031608 CC BY 4.0