2026-10-11T14:46:05Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34031587 2026-09-30T11:11:21Z category_4 category_13 category_19 category_21 category_272 category_873 category_39 category_46 category_734 category_122 portal_87 item_type_6 month_year_09_2026

Source, biological activity, molecular mechanism, pharmacokinetics, and preparation of luteoloside Xiaolin Shi (261143) Xiaoxu Zhang (1422019) Yanfei Lang (25143451) Jiaxin Xu (11526724) Xinhuan Wan (21339654) Biochemistry Genetics Pharmacology Biotechnology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Ecology Immunology Biological Sciences not elsewhere classified Mental Health Luteoloside bioactivity extraction preparation pharmacokinetics <p>Luteoloside, a flavonoid compound, is widely distributed in various plant families. Preclinical studies have demonstrated that luteoloside exhibits a broad spectrum of pharmacological activities <i>in vitro</i> and <i>in vivo</i>, including anti-inflammatory, antibacterial, antiviral, anticancer, antioxidant, and cardioprotective effects. However, its therapeutic potential is significantly constrained by poor aqueous solubility, extensive presystemic metabolism, and consequently low oral bioavailability. Pharmacokinetic studies reveal route-dependent behaviour and rapid clearance. To overcome these hurdles, advanced delivery systems such as microemulsions, polymeric nanocarriers, and hydrogels have been developed. Toxicological assessments indicate a wide therapeutic window with low acute toxicity. In conclusion, this review consolidates the substantial preclinical evidence supporting luteoloside’s multi-target mechanisms. Nevertheless, it also critically highlights the existing gaps, particularly the absence of clinical data and the challenges in pharmacokinetics, which must be addressed through rigorous future research to evaluate its true clinical potential.</p> 2026-09-30T11:11:21Z Text Journal contribution 10.6084/m9.figshare.34031587.v1 https://figshare.com/articles/journal_contribution/Source_biological_activity_molecular_mechanism_pharmacokinetics_and_preparation_of_luteoloside/34031587 CC BY 4.0