2026-10-10T16:15:40Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34031521 2026-09-30T11:05:49Z category_4 category_8 category_15 category_16 category_19 category_21 category_272 category_873 category_931 category_61 category_122 category_132 portal_63 item_type_6 month_year_09_2026

Visible-Light-Promoted Radical Spirocyclization of 1,7-Enynes and α‑Bromocarbonyl Compounds to Access Spirooxindole Derivatives Mengshuang Guo (516671) Yijia Zhang (125027) Ruyi Fu (13247493) Xiaolong Wu (5008658) Xinyang Wang (196252) Zhen Zhang (86004) Biochemistry Microbiology Neuroscience Physiology Pharmacology Biotechnology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified Developmental Biology Mental Health Infectious Diseases functionalized spirooxindole derivatives diversified product derivatizations control experiments confirm complex spirocyclic skeletons access spirooxindole derivatives radical rearrangement processes promoted radical spirocyclization synthetic utility step assembly simple operation hydride shift high diastereoselectivity efficient construction diverse α bromocarbonyl compounds A novel visible-light-induced radical cascade spirocyclization of 1,7-enynes with diverse α-bromocarbonyl compounds is developed for the efficient construction of functionalized spirooxindole derivatives. This protocol features mild reaction conditions and simple operation, enabling the one-step assembly of complex spirocyclic skeletons with high diastereoselectivity. Scale-up synthesis and diversified product derivatizations further demonstrate the synthetic utility of this methodology. A series of control experiments confirm a radical-involved reaction pathway involving key 1,5-hydride shift and radical rearrangement processes. 2026-09-30T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03826.s001 https://figshare.com/articles/journal_contribution/Visible-Light-Promoted_Radical_Spirocyclization_of_1_7-Enynes_and_Bromocarbonyl_Compounds_to_Access_Spirooxindole_Derivatives/34031521 CC BY-NC 4.0