2026-10-14T14:19:00Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34031220 2026-09-30T10:13:33Z category_7 portal_147 item_type_3 month_year_09_2026

Supplemental Material for: Late-onset MuSK myasthenia gravis in a patient with poly-autoimmunity: case report and literature review figshare admin karger (2628495) Russell Wong (3772600) Antonia S. Carroll (25143108) Ross Penglase (18582016) Andrew Weissberger (25143111) Stephen Tisch (9956954) Medicine Medicine <p dir="ltr"><b>Introduction</b></p><p dir="ltr">Muscle-specific kinase (MuSK) myasthenia gravis (MG) is an uncommon subtype of acquired autoimmune neuromuscular junction disorder, often associated with a more severe clinical phenotype. Although MG may occasionally co-occur with other autoimmune conditions, the presence of multiple autoimmune diseases, termed poly-autoimmunity, is rare and presents significant diagnostic and therapeutic challenges.</p><p dir="ltr"><b>Case Presentation</b></p><p dir="ltr">We describe the case of a 79-year-old woman with longstanding autoimmune thyroiditis and Sjögren’s syndrome who presented with severe bulbar and axial weakness. Initially suspected to have a Sjögren’s-associated myopathy, she was later diagnosed with MuSK MG. Early empirical treatment with intravenous immunoglobulin was followed by rituximab, resulting in marked clinical improvement and sustained remission more than a year later during follow up. Concurrently, she was diagnosed with latent autoimmune diabetes in adults (LADA), raising her autoimmune burden to four counts.</p><p dir="ltr"><b>Conclusion</b></p><p dir="ltr">This case underscores the importance of clinical vigilance and multidisciplinary evaluation in patients with poly-autoimmunity and highlights the potential for personalised, mechanism-driven therapeutic approaches.</p> 2026-09-30T10:13:33Z Dataset Dataset 10.6084/m9.figshare.34031220.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Late-onset_MuSK_myasthenia_gravis_in_a_patient_with_poly-autoimmunity_case_report_and_literature_review/34031220 CC BY 4.0