2026-10-14T12:56:04Z
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2026-09-30T07:14:34Z
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Synthesis of Functionalized
Cyanamide Derivatives
Enabled by Hydrocyanamidation of Activated Alkenes or Alkynes
Hong-Ding Xie (21537443)
Xin-Yu Ding (20319960)
Li-Juan Sun (3087375)
Ying-Wu Lin (2185171)
Junliang Zhang (1470220)
Huamin Wang (143068)
Biophysics
Biochemistry
Medicine
Molecular Biology
Biotechnology
Sociology
Developmental Biology
Mental Health
practical synthetic strategies
mild reaction conditions
broad substrate scope
>- cyano -<
>- aryl -<
diverse disubstituted cyanamides
>- methylbenzenesulfonamide
cyanamides remains
versatile approach
stage functionalization
significant challenge
readily accessible
present method
p </
n </
activated alkenes
The development of practical synthetic strategies for
cyanamides
remains a significant challenge. Here, we report a metal-free, fluoride-promoted
hydrocyanamidation between readily accessible <i>N</i>-cyano-<i>N</i>-aryl-<i>p</i>-methylbenzenesulfonamide (NCTS)
and activated alkenes or alkynes. This method features operational
simplicity, a broad substrate scope, excellent functional group tolerance,
and mild reaction conditions, offering a versatile approach to diverse
disubstituted cyanamides. Furthermore, the practicality of this present
method was evidenced by gram-scale synthesis and late-stage functionalization
of the product.
2026-09-30T00:00:00Z
Text
Journal contribution
10.1021/acs.joc.6c01925.s001
https://figshare.com/articles/journal_contribution/Synthesis_of_Functionalized_Cyanamide_Derivatives_Enabled_by_Hydrocyanamidation_of_Activated_Alkenes_or_Alkynes/34030477
CC BY-NC 4.0