2026-10-14T04:20:09Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34030408 2026-09-30T07:20:04Z category_7 category_16 category_21 category_873 category_64 category_106 category_122 portal_87 item_type_3 month_year_09_2026

Home-based exercise interventions incorporating cardiac rehabilitation principles for people with cancer: a systematic review and meta-analysis Petr Winnige (18577631) Filip Dosbaba (17806353) Martin Hartman (1275864) Garyfallia Pepera (17806356) Varsamo Antoniou (25142266) Eleni Karagianni (25142269) Francesco Perone (20407496) Rose Lin (4470724) Jing Jing Su (17696843) Ladislav Batalik (13945917) Medicine Physiology Biotechnology Chemical Sciences not elsewhere classified Cancer Science Policy Mental Health Home-based rehabilitation cancer exercise-based cardiac rehabilitation cardio-oncology quality of life VO2 peak adherence fatigue resistance training <p>People with cancer are at increased cardiovascular risk due to treatment-related cardiotoxicity and shared risk factors. Exercise-based cardiac rehabilitation (exCR) may mitigate these risks, but access to center-based programs is limited. This systematic review and meta-analysis evaluated the effectiveness, safety, and adherence of home-based exCR in oncology populations.</p> <p>Six databases were searched in January 2025 for randomized controlled trials (RCTs) of home-based exCR in adults with cancer. Eligible interventions included structured aerobic and/or resistance exercise consistent with established CR guidelines. Primary outcomes were cardiorespiratory fitness (CRF), health-related quality of life (HRQoL), adherence, and safety. Random-effects meta-analyses used standardized mean differences (SMDs).</p> <p> Nine RCTs (632 participants) were included. Home-based exCR improved CRF (SMD 0.42; 95% CI 0.09–0.75; <i>I</i>²=62%) and HRQoL (SMD 0.63; 95% CI 0.05–1.22; <i>I</i>²=84%). TESTEX scores indicated generally good methodological and reporting quality (mean 10/15; range 7–13). Adherence exceeded 75% in most studies reporting this outcome, and dropout was 15.2%. Adverse-event reporting was inconsistent; no clear safety signal emerged, but evidence was insufficient for firm conclusions. Strength and fatigue findings were inconsistent.</p> <p>Home-based exCR appears feasible and may improve CRF and HRQoL in people with cancer, offering an accessible alternative or complement to center-based rehabilitation. Incomplete adverse-event reporting limits safety conclusions. Future studies should evaluate full, multi-component CR models in oncology.</p> 2026-09-30T07:20:04Z Dataset Dataset 10.6084/m9.figshare.34030408.v1 https://figshare.com/articles/dataset/Home-based_exercise_interventions_incorporating_cardiac_rehabilitation_principles_for_people_with_cancer_a_systematic_review_and_meta-analysis/34030408 CC BY 4.0