2026-10-12T11:46:24Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34030290 2026-09-30T06:22:17Z category_1 category_146 category_915 category_13 category_16 category_24 category_873 category_39 category_931 category_132 category_135 portal_63 item_type_6 month_year_09_2026

Rapid Aryne-Enabled Aryl Functionalization via Mechanically Assisted Microscale Mixing Johanna Breinsperger (25142163) Maximilian Kaiser (11048293) Michael Schnürch (1281255) Biophysics Space Science Physical Sciences not elsewhere classified Genetics Physiology Evolutionary Biology Chemical Sciences not elsewhere classified Ecology Information Systems not elsewhere classified Infectious Diseases Computational Biology standard vortex mixer highly reactive intermediates aryl functionalization without solvent minimized approach bulk solvent trapped efficiently therefore providing rapid aryne inert atmosphere fast generation Herein, we demonstrate that arynes can be generated and trapped efficiently through mechanically assisted microscale mixing on a standard vortex mixer. Brief vortex agitation enables ultra-fast generation and interception of these highly reactive intermediates with N-, O-, S-, and C-nucleophiles within 1 min, therefore providing a low-energy-solvent minimized approach for aryl functionalization without the need for inert atmosphere, heating, or bulk solvent. 2026-09-30T00:00:00Z Text Journal contribution 10.1021/acsomega.6c09456.s001 https://figshare.com/articles/journal_contribution/Rapid_Aryne-Enabled_Aryl_Functionalization_via_Mechanically_Assisted_Microscale_Mixing/34030290 CC BY-NC 4.0