2026-10-12T03:02:59Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34030269 2026-09-30T06:20:25Z category_4 category_7 category_46 category_734 category_106 portal_87 item_type_6 month_year_09_2026

The role of flavonoid baicalein in sepsis management: A systematic review of molecular mechanisms Usamah Sayed (25142094) Naji Musa Ali (25142097) S. Renuka Jyothi (21753735) Ritesh Singh (1307049) Neeraj Bainsal (25142100) Jasur Rizaev (22286713) Inoyatillo Kholmurodov (25142103) Biochemistry Medicine Immunology Biological Sciences not elsewhere classified Science Policy Baicalein Sepsis Immune response Inflammation Oxidative stress Systematic review <p>Sepsis is an imperative and multifaceted medical condition that occurs when the immune system overreacts to pathogens. Baicalein, a strategic dynamic flavonoid, exhibits strong antioxidant and anti-inflammatory actions across diverse syndrome models and may have beneficial properties in sepsis. This study followed the guidelines set forth by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched Embase, Scopus, PubMed, and Web of Science for relevant keywords up to 11 April 2026. From 672 articles, 25 publications (<i>in vitro</i> (n=14), <i>in vivo</i> (n=18); of which 5 studies were both <i>in vitro</i> and <i>in vivo</i>) were included in this systematic review. Most <i>in vitro</i> studies used lipopolysaccharide (LPS) stimulated cell models, such as RAW264.7 macrophages, AR42J cells, and HUVECs, to evaluate inflammatory responses. <i>In vivo</i> studies were primarily conducted in mouse and rat models of sepsis, including LPS-induced endotoxemia and cecal ligation and puncture (CLP). Mechanistic findings suggested that these effects are largely mediated by modulation of key inflammatory signaling pathways, particularly by inhibiting NF-κB–related pathways and regulating oxidative stress responses. Given the promising preclinical effects of baicalein in sepsis models but the complete absence of human data, future research must prioritize pharmacokinetic characterization and well-designed clinical trials to determine whether these experimental benefits can translate into safe and effective therapies for septic patients.</p> 2026-09-30T06:20:25Z Text Journal contribution 10.6084/m9.figshare.34030269.v1 https://figshare.com/articles/journal_contribution/The_role_of_flavonoid_baicalein_in_sepsis_management_A_systematic_review_of_molecular_mechanisms/34030269 CC BY 4.0