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oai:figshare.com:article/34029783 2026-09-30T04:50:55Z category_374 portal_316 item_type_3 month_year_09_2026

Table 1_Association of the triglyceride–cholesterol–body weight index (TCBI) with incident diabetes in Chinese adults: a population-based cohort study with non-linear and threshold analyses.docx Xue Guo (307988) Yao Wu (598978) Guangqin Ren (20516369) Huibing Chen (7326344) Yang Song (88132) Lijuan Dong (516415) Clinical and Sports Nutrition Chinese adults cohort study incident diabetes non-linear relationship threshold effect triglyceride–cholesterol–body weight index Background<p>The triglyceride–cholesterol–body weight index (TCBI) is a simple composite nutritional marker. However, its association with incident diabetes remains unclear. We examined this association in Chinese adults, focusing on non-linear and threshold effects.</p>Methods<p>This retrospective cohort study included 206,085 adults without baseline diabetes. TCBI was calculated as (TG × TC × body weight) / 1,000. We used Cox regression, restricted cubic splines, and segmented regression for analysis.</p>Results<p>During follow-up, 4,093 participants developed incident diabetes. Higher TCBI was consistently associated with an increased risk of incident diabetes. In the fully adjusted model, each 1-SD increase in TCBI was associated with a 13% higher risk of incident diabetes (HR = 1.13, 95% CI: 1.12–1.14; P < 0.001), while each 1-unit increase in ln-TCBI was associated with a 94% higher risk (HR = 1.94, 95% CI: 1.86–2.03; P < 0.001). Compared with participants in the lowest TCBI quartile (Q1), the fully adjusted HRs were 2.18 (95% CI: 1.83–2.59), 3.49 (95% CI: 2.95–4.12), and 6.53 (95% CI: 5.53–7.72) for Q2, Q3, and Q4, respectively (P for trend < 0.001). Restricted cubic spline analysis indicated a non-linear association between ln-TCBI and incident diabetes (P for non-linearity < 0.001). Segmented regression identified a potential threshold at ln-TCBI = 6.828 (original TCBI ≈ 923), with positive associations observed both below (HR = 2.223, 95% CI: 1.613–3.062) and above (HR = 1.901, 95% CI: 1.787–2.022) the threshold.</p>Conclusions<p>These findings suggest that TCBI may represent an accessible composite metabolic indicator associated with diabetes risk; however, whether TCBI provides additional information beyond established metabolic indicators and whether the identified threshold has clinical relevance require further validation in diverse populations.</p> 2026-09-30T04:50:55Z Dataset Dataset 10.3389/fnut.2026.1928555.s001 https://figshare.com/articles/dataset/Table_1_Association_of_the_triglyceride_cholesterol_body_weight_index_TCBI_with_incident_diabetes_in_Chinese_adults_a_population-based_cohort_study_with_non-linear_and_threshold_analyses_docx/34029783 CC BY 4.0