2026-10-07T16:36:11Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34029756 2026-09-30T04:50:52Z category_531 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Hemocompatible polymeric hydrogels with tunable photoresponsive volumetric properties.pdf Akari J. Seiner (25141536) Victor Mishin (25141539) Shreya S. Soni (25141542) Elisabeth Posthill (18223383) Biplab Sarkar (1735765) Kara L. Spiller (9659495) Amy L. Throckmorton (25141545) Christopher B. Rodell (1620697) Biomaterials biomaterials hemocompatibility hydrogel medical devices pediatrics photopolymerization photoresponsive implant <p>Hydrogels exhibit crosslink density-dependent properties that can be tuned to achieve spatiotemporal control, making them well-suited for a wide range of biomedical applications. In particular, light reactive hydrogels have requisite features for use in size-changing biomaterial devices such as pediatric blood shunts, that can uniquely meet evolving patient-specific needs after in vivo implantation. Here, we report on the design of a tunable photoresponsive and hemocompatible methacrylated dextran hydrogel suitable for use in such devices. The formation and subsequent deswelling of hydrogels proceeded through discrete sequential photopolymerization steps. The range of geometric tunability (up to 20% volume change) was a function of methacrylate density (e.g., polymer modification and concentration) and the extent of initial polymerization that was controlled via exposure time, intensity, and photoinitiator concentration. Furthermore, the hydrogels exhibited long-term (>3 months) stability and hemocompatibility, including with blood-borne cell types (e.g., erythrocytes and leukocytes). In vitro verification demonstrated the feasibility of this concept; our elucidation of the parameter space governing hydrogel properties will facilitate the use of the platform in various blood-interface constructs, specifically pediatric blood shunts.</p> 2026-09-30T04:50:52Z Dataset Dataset 10.3389/fbiom.2026.1924191.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Hemocompatible_polymeric_hydrogels_with_tunable_photoresponsive_volumetric_properties_pdf/34029756 CC BY 4.0