2026-10-11T19:38:29Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34028439 2026-09-30T01:07:02Z category_4 category_7 category_14 category_272 category_873 category_64 category_132 category_134 portal_63 item_type_6 month_year_09_2026

Nickel-Catalyzed Reductive Alkylation of Aldimines with Unactivated Alkyl Iodides Minji Kim (1722313) Jin Hyun Park (3035565) Won Jun Jang (2004397) Biochemistry Medicine Molecular Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Cancer Infectious Diseases Virology unactivated alkyl iodides tertiary alkyl iodides sphere radical addition derived alkyl iodides catalyzed reductive alkylation accommodates unactivated primary accessible alkyl radical >- aryl aldimines >- sulfonyl scale reaction reaction proceeds n </ mediated generation complex molecule broad functional ambient temperature A nickel-catalyzed reductive alkylation of directing-group-free <i>N</i>-sulfonyl and <i>N</i>-aryl aldimines is reported. The reaction proceeds at ambient temperature and accommodates unactivated primary, secondary, and tertiary alkyl iodides as well as selected activated alkyl bromides with broad functional-group tolerance. Complex molecule-derived alkyl iodides, a gram-scale reaction, and β-amino ester derivatizations demonstrate synthetic utility. Mechanistic studies support nickel-mediated generation of a solution-accessible alkyl radical and are consistent with outer-sphere radical addition to the imine. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03717.s001 https://figshare.com/articles/journal_contribution/Nickel-Catalyzed_Reductive_Alkylation_of_Aldimines_with_Unactivated_Alkyl_Iodides/34028439 CC BY-NC 4.0