2026-10-10T14:19:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34028436 2026-09-30T01:06:29Z category_4 category_16 category_46 category_734 category_931 category_64 portal_63 item_type_6 month_year_09_2026

Architecture-Guided Sequential Editing of Distinct Disulfides in Unprotected Peptides Samrat Kundu (8081399) Adrija Majumdar (17336965) Monika Raj (1427989) Biochemistry Physiology Immunology Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer programmable disulfide editing guided sequential editing tert </ selectively decoded selective manipulation protecting groups orthogonal phosphite mediated transformation global reduction distinct disulfides Disulfide modification typically relies on global reduction, preventing the selective manipulation of individual disulfide bonds within complex peptides. Here, we show that aromatic, ethyl, and <i>tert</i>-butyl disulfides embedded in fully unprotected peptides exhibit distinct intrinsic reactivities that can be selectively decoded by using matched activation modes. This architecture-guided hierarchy enables sequential chemoselective functionalization without the use of protecting groups. Aromatic disulfides further undergo an orthogonal phosphite-mediated transformation, expanding the repertoire of programmable disulfide editing. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03451.s001 https://figshare.com/articles/journal_contribution/Architecture-Guided_Sequential_Editing_of_Distinct_Disulfides_in_Unprotected_Peptides/34028436 CC BY-NC 4.0