2026-10-14T07:38:24Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34028424 2026-09-30T01:04:50Z category_4 category_13 category_21 category_24 category_873 category_45 category_734 portal_63 item_type_6 month_year_09_2026

Asymmetric Divergent Synthesis of Miophytocen D, Roridin E, Verrucarin J, and Verrucarol Zhang-Qin Xue (25139661) Feng-Sheng Jiang (25139664) Wen-Kai Ge (25139667) Jia-Bo Sun (25139670) Zong-Xu Gao (18988555) Ming-Zhu Zhu (11730378) Ling-Fei Hu (15020558) Yan Zong (6274541) Rongbiao Tong (1617409) Hong-Xiang Lou (161416) Ze-Jun Xu (1508584) Biochemistry Genetics Biotechnology Evolutionary Biology Chemical Sciences not elsewhere classified Sociology Biological Sciences not elsewhere classified provides chemical support proposed biosynthetic transformation biomimetic chemoselective oxacyclization first total synthesis divergent asymmetric synthesis asymmetric divergent synthesis tetrahydropyran ring assembly synthesis features modular ring verrucarin j study delivers scale access roridin e furnishes hundred exo </ closing metathesis Herein, we report a divergent asymmetric synthesis of miophytocen D, roridin E, verrucarin J, and verrucarol. The synthesis features an <i>exo</i>-selective Diels–Alder cycloaddition, a biomimetic chemoselective oxacyclization for tetrahydropyran ring assembly, a conformation-controlled alkene–epoxy cyclization to access divergent molecular scaffolds, and a modular ring-closing metathesis (RCM)-based macrocyclization. This study delivers the first total synthesis of miophytocen D, furnishes hundred-milligram-scale access to verrucarol, and provides chemical support for the proposed biosynthetic transformation. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/jacs.6c14997.s001 https://figshare.com/articles/journal_contribution/Asymmetric_Divergent_Synthesis_of_Miophytocen_D_Roridin_E_Verrucarin_J_and_Verrucarol/34028424 CC BY-NC 4.0