2026-10-13T14:05:34Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34028421 2026-09-30T01:04:17Z category_1 category_4 category_915 category_7 category_14 category_272 category_873 category_46 portal_63 item_type_6 month_year_09_2026

Deboronative Asymmetric Suzuki–Miyaura Cross-Coupling of Alkylboronic Esters Enabled by Dual Photoredox and Nickel Catalysis Ziyi Luo (8058782) Yang Sun (132532) Xu Zhang (49484) Dongyang Zhang (152922) Liang Fu (1623988) Haibin Xu (108731) Junqi Yu (22062299) Hui Wang (30400) Biophysics Biochemistry Physical Sciences not elsewhere classified Medicine Molecular Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Immunology racemic alkylboronic esters aryl halides enabled alkylboronic esters enabled nickel catalysis high reactivity excellent enantioselectivity dual photoredox cooperative use The transition-metal-catalyzed asymmetric Suzuki–Miyaura cross-coupling of alkylboron reagents remains highly challenging, especially with racemic alkylboronic esters. Herein, we disclose the first enantioconvergent deboronative Suzuki–Miyaura cross-coupling of racemic alkylboronic esters with (hetero)aryl halides enabled by dual photoredox and nickel catalysis. The protocol displays broad scope across (hetero)aryl bromides bearing functionally diverse substituents. The cooperative use of 4-cyanopyridine and pentafluoropyridine is crucial for achieving both high reactivity and excellent enantioselectivity. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03250.s001 https://figshare.com/articles/journal_contribution/Deboronative_Asymmetric_Suzuki_Miyaura_Cross-Coupling_of_Alkylboronic_Esters_Enabled_by_Dual_Photoredox_and_Nickel_Catalysis/34028421 CC BY-NC 4.0