2026-10-06T21:45:48Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34028274 2026-09-29T23:57:38Z category_30355 portal_21 item_type_8 month_year_09_2026

24hr Blood Pressure Profiles and Brain Health Madeline Margaret Gibson (25139556) Clinical neuropsychology Blood pressure brain health dementia cognition brain MRI 24hr blood pressure ambulatory blood pressure monitoring blood pressure variability nocturnal blood pressure neuropsychology white matter injury small vessel disease alzheimer's disease cardiovascular health High blood pressure (BP) in midlife increases the risk of dementia, but standard clinic measurements miss BP changes throughout the day and night. This thesis examined 24-hour BP and brain health in adults without dementia. Findings showed that 24-hour BP, particularly higher average levels and greater fluctuations, were linked to poorer brain health, including poorer cognition, injury to the brain’s white matter, altered blood-brain barrier function, or neuronal damage and neuroinflammation. Sleep and night-time blood pressure patterns also appeared to interact with brain health. Further research is needed to determine whether targeting these BP patterns could reduce dementia risk. 2026-09-29T23:57:38Z Text Thesis 10.26180/34028274.v1 https://figshare.com/articles/thesis/24hr_Blood_Pressure_Profiles_and_Brain_Health/34028274 In Copyright Open Access after 2027-09-29