2026-10-10T09:20:48Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34028058 2026-09-29T22:06:15Z category_1 category_4 category_915 category_7 category_14 category_16 category_873 category_734 category_132 category_135 portal_63 item_type_6 month_year_09_2026

Visible-Light-Mediated Skeletal Editing of Furans to Pyridazines Lu-Lu Qin (8714352) Yan Lei (535846) Yihan Tang (6851498) Peng-Ju Xia (1478815) Biophysics Biochemistry Physical Sciences not elsewhere classified Medicine Molecular Biology Physiology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Infectious Diseases Computational Biology water suppresses hydrazine stage skeletal editing mechanistic studies suggest derived reactive species additional experiments support mediated skeletal editing pyridazines via formal readily available furans mediated quenching tetrasubstituted pyridazines scale synthesis room temperature reaction proceeds overall transformation nn atom herein describe group tolerance free conditions excited photocatalyst complex molecules complete regiocontrol broad functional We herein describe a visible-light-mediated skeletal editing of furans to pyridazines via formal O-to-NN atom-pair exchange using hydrazine hydrate. The reaction proceeds under metal-free conditions at room temperature in air, providing di-, tri-, and tetrasubstituted pyridazines with complete regiocontrol from readily available furans. Broad functional-group tolerance, gram-scale synthesis, and late-stage skeletal editing of complex molecules are demonstrated. Mechanistic studies suggest that water suppresses hydrazine-mediated quenching of the excited photocatalyst, while additional experiments support the involvement of oxygen-derived reactive species in the overall transformation. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03465.s001 https://figshare.com/articles/journal_contribution/Visible-Light-Mediated_Skeletal_Editing_of_Furans_to_Pyridazines/34028058 CC BY-NC 4.0