2026-10-08T01:22:40Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34027713 2026-09-29T21:46:58Z category_24166 item_type_3 month_year_09_2026

Apigenin ovarian cancer Kwon (23828704) Signal transduction Cancer-stroma crosstalk Ovarian cancer cells Apigenin TGF-B signaling Fibroblasts AKT inhibition <p dir="ltr">Among stromal cells, fibroblasts serve as a major source of TGF-β1, which promotes ovarian cancer cell proliferation. However, TGF-β1-induced growth enhancement requires AKT activation in ovarian cancer cells, either through intrinsic constitutive hyperactivation or external fibroblast-derived factors other than TGF-β1. Furthermore, AKT activation is important for producing or maintaining TGF-β1 in fibroblasts. Among the polyphenols tested, apigenin effectively inhibited TGF-β1 secretion from fibroblasts and suppressed their pro-proliferative effects on ovarian cancer cells. Apigenin inhibited AKT activation in cancer cells and fibroblasts. In fibroblasts, apigenin-mediated AKT inhibition reduced the secretion of TGF-β1 available to promote cancer cell growth, whereas in ovarian cancer cells, apigenin reduced AKT-dependent proliferation, which functions as an intrinsic driver of cell proliferation and a permissive condition for TGF-β1-induced growth.</p> 2026-09-29T21:46:58Z Dataset Dataset 10.6084/m9.figshare.34027713.v1 https://figshare.com/articles/dataset/Apigenin_ovarian_cancer/34027713 CC BY 4.0