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oai:figshare.com:article/34027687 2026-09-29T21:07:24Z category_1 category_4 category_12 category_15 category_16 category_21 category_873 category_45 category_931 category_61 category_122 category_132 portal_63 item_type_6 month_year_09_2026

Germyl Radical Cyclization of N‑Propargyl Aromatic Amines with Germanes: A Concise Route to Germanium-Containing Quinolines Yue Zhang (30585) Yanjun Wu (418662) Haibin Xiao (1583728) Junhao Chen (4689715) Zihan Wu (8492130) Xiaolei Huang (1397371) Biophysics Biochemistry Cell Biology Neuroscience Physiology Biotechnology Chemical Sciences not elsewhere classified Sociology Information Systems not elsewhere classified Developmental Biology Mental Health Infectious Diseases transformation proceeds via mechanistic investigations indicate features high regioselectivity enabling efficient construction broad substrate scope germyl radical cyclization radical pathway substituted quinolines remained unexplored privileged class n </ marketed pharmaceuticals dilauroyl peroxide determining step concise route Quinolines represent a privileged class of heterocyclic scaffolds widely prevalent in biologically active natural products and marketed pharmaceuticals. Despite their significance, the synthesis of germanium-substituted quinolines through germyl radical cyclization has remained unexplored to date. Herein, we report a dilauroyl peroxide (LPO)-mediated cascade protocol involving germylation, cyclization, and aromatization of <i>N</i>-propargyl aromatic amines with germanes, enabling efficient construction of 3-germanium-substituted quinolines. This transformation proceeds via a radical pathway and features high regioselectivity, broad substrate scope, and good functional group compatibility. Mechanistic investigations indicate that cleavage of the Ge–H bond serves as the rate-determining step. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.joc.6c01998.s001 https://figshare.com/articles/journal_contribution/Germyl_Radical_Cyclization_of_N_Propargyl_Aromatic_Amines_with_Germanes_A_Concise_Route_to_Germanium-Containing_Quinolines/34027687 CC BY-NC 4.0