2026-10-14T06:43:59Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34027539 2026-09-29T20:05:59Z category_4 category_8 category_19 category_21 category_873 category_69 category_132 portal_63 item_type_6 month_year_09_2026

Photocatalytic Three-Component Glycosylation of Styrenes with Glycosyl Acids and Pyridines via Decarboxylation Jingyi Guo (2625853) Xin Liu (43569) Jin Yang (86490) Jingyu Zhang (256203) Yingsheng Zhao (1528195) Biochemistry Microbiology Pharmacology Biotechnology Chemical Sciences not elsewhere classified Inorganic Chemistry Infectious Diseases radical tandem pathway pharmaceutically active fragments methods require two mechanistic studies confirm study addresses step assembly scale preparation protected monosaccharides photocatalytic three mediated three key gap glycoside synthesis enables gram concise strategy component reactions component glycosylation C-Alkyl glycosides represent important pharmaceutical scaffolds; however, most methods require two-component reactions. We report a visible-light-mediated three-component tandem decarboxylative difunctionalization of glycosyl acids, styrenes, and cyanopyridines for one-step assembly of polysubstituted C-glycosides. The method tolerates various styrenes, protected monosaccharides, and pharmaceutically active fragments, and enables gram-scale preparation. Mechanistic studies confirm a glycosyl-radical tandem pathway. This study addresses a key gap in styrene-participating multicomponent sugar reactions, providing a concise strategy for C-glycoside synthesis. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03933.s001 https://figshare.com/articles/journal_contribution/Photocatalytic_Three-Component_Glycosylation_of_Styrenes_with_Glycosyl_Acids_and_Pyridines_via_Decarboxylation/34027539 CC BY-NC 4.0