2026-10-12T17:07:45Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34027515 2026-09-29T20:01:58Z category_4 category_13 category_14 category_873 category_46 category_734 category_64 portal_5 item_type_1 month_year_09_2026

<p>Functional enrichment analysis links FABP5 to immune activation and NF-κB signaling pathways.</p> Rui An (636731) Shibing Hou (2288815) Min Hong (279203) Jiaorong Zhen (23973891) Zhijuan Wang (1900771) Haoming Huang (12791303) Weixuan Zhao (12058148) Mianmian Liao (10916520) Weiqu Yuan (23973893) Danping Huang (196661) Biochemistry Genetics Molecular Biology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer xlink "> tcga predicted worse survival independent prognostic factor experimental validation confirmed nf -&# 954 epithelial &# 8211 protein &# 8211 xlink "> fabp5 fabp5 correlated positively immune checkpoint profiles higher tide scores b &# 945 b &# 8211 b pathway genes identify potential fabp5 characterize fabp5 expression duplicate md simulations fabp5 drives pd hcc cell proliferation &# 954 tide scores b pathway therapeutic potential protein docking decreased expression cell rna promising fabp5 fabp5 shapes fabp5 regulates fabp5 knockdown vitro assays targeting compound significantly upregulated seq datasets related pathways regulatory role molecular dynamics molecular docking mesenchymal transition lipid metabolism l1 via l1 upregulation l1 axis immunosuppressive microenvironment <p>(A) Heatmap of DEGs between high and low FABP5 expression groups. (B) Gene Ontology (GO) enrichment analysis of DEGs, showing significant biological processes (BP), cellular components (CC), and molecular functions (MF) related to immune regulation. (C) KEGG pathway enrichment analysis highlighting immune-related pathways associated with FABP5 expression, such as cytokine–cytokine receptor interaction, chemokine signaling, Th1/Th2 and Th17 cell differentiation, B cell receptor signaling, NF-κB signaling, PI3K–Akt signaling, T cell receptor signaling, IL-17 signaling, and JAK–STAT signaling. (D) Correlation analysis revealed a positive association between FABP5 expression and cancer inflammatory gene signatures. (E) Heatmap showing co-upregulation of NF-κB pathway genes (NF-κB1, NF-κB2, RELA) in FABP5-high tumors.</p> 2026-09-29T20:01:47Z Image Figure 10.1371/journal.pone.0356359.g007 https://figshare.com/articles/figure/_p_Functional_enrichment_analysis_links_FABP5_to_immune_activation_and_NF-_B_signaling_pathways_p_/34027515 CC BY 4.0