2026-10-13T08:50:58Z
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oai:figshare.com:article/34027512
2026-09-29T20:01:57Z
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<p>FABP5 expression correlates with immune infiltration and immunosuppressive microenvironment.</p>
Rui An (636731)
Shibing Hou (2288815)
Min Hong (279203)
Jiaorong Zhen (23973891)
Zhijuan Wang (1900771)
Haoming Huang (12791303)
Weixuan Zhao (12058148)
Mianmian Liao (10916520)
Weiqu Yuan (23973893)
Danping Huang (196661)
Biochemistry
Genetics
Molecular Biology
Chemical Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
xlink "> tcga
predicted worse survival
independent prognostic factor
experimental validation confirmed
nf -&# 954
epithelial &# 8211
protein &# 8211
xlink "> fabp5
fabp5 correlated positively
immune checkpoint profiles
higher tide scores
b &# 945
b &# 8211
b pathway genes
identify potential fabp5
characterize fabp5 expression
duplicate md simulations
fabp5 drives pd
hcc cell proliferation
&# 954
tide scores
b pathway
therapeutic potential
protein docking
decreased expression
cell rna
promising fabp5
fabp5 shapes
fabp5 regulates
fabp5 knockdown
vitro assays
targeting compound
significantly upregulated
seq datasets
related pathways
regulatory role
molecular dynamics
molecular docking
mesenchymal transition
lipid metabolism
l1 via
l1 upregulation
l1 axis
immunosuppressive microenvironment
<p>(A) Boxplots of normalized gene expression after batch correction. (B) PCA plots demonstrating the effectiveness of batch effect removal. (C) Relative abundance of 22 immune cell subsets estimated by CIBERSORT. (D) Differential infiltration analysis of immune cell populations between tumor and normal tissues. (E) Correlation matrix of infiltrating immune cells. (F) Correlation analysis between FABP5 expression and immune cell abundance. (G) TIDE analysis showing higher TIDE scores in FABP5-high patients, suggesting resistance to immune checkpoint blockade therapy. (H) Upregulation of multiple immune checkpoint molecules (e.g., PD-L1, CTLA-4, PD-1) in FABP5-high tumors. (I) ESTIMATE analysis confirmed higher stromal and immune scores in the FABP5-high group. G1: Group 1 (High Expression); G2: Group 2 (Low Expression). *<i>p</i> < 0.05, **<i>p</i> < 0.01, ***<i>p</i> < 0.001.</p>
2026-09-29T20:01:47Z
Image
Figure
10.1371/journal.pone.0356359.g006
https://figshare.com/articles/figure/_p_FABP5_expression_correlates_with_immune_infiltration_and_immunosuppressive_microenvironment_p_/34027512
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