2026-10-14T22:47:38Z
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2026-09-29T20:01:55Z
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<p>FABP5 knockdown suppresses HCC cell proliferation <i>in vitro.</i></p>
Rui An (636731)
Shibing Hou (2288815)
Min Hong (279203)
Jiaorong Zhen (23973891)
Zhijuan Wang (1900771)
Haoming Huang (12791303)
Weixuan Zhao (12058148)
Mianmian Liao (10916520)
Weiqu Yuan (23973893)
Danping Huang (196661)
Biochemistry
Genetics
Molecular Biology
Chemical Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
xlink "> tcga
predicted worse survival
independent prognostic factor
experimental validation confirmed
nf -&# 954
epithelial &# 8211
protein &# 8211
xlink "> fabp5
fabp5 correlated positively
immune checkpoint profiles
higher tide scores
b &# 945
b &# 8211
b pathway genes
identify potential fabp5
characterize fabp5 expression
duplicate md simulations
fabp5 drives pd
hcc cell proliferation
&# 954
tide scores
b pathway
therapeutic potential
protein docking
decreased expression
cell rna
promising fabp5
fabp5 shapes
fabp5 regulates
fabp5 knockdown
vitro assays
targeting compound
significantly upregulated
seq datasets
related pathways
regulatory role
molecular dynamics
molecular docking
mesenchymal transition
lipid metabolism
l1 via
l1 upregulation
l1 axis
immunosuppressive microenvironment
<p>(A) qPCR analysis confirmed effective silencing of FABP5 by siRNA in Huh7 cells. (B) CCK-8 assay showed that FABP5 knockdown reduced cell viability at 24, 48, and 72 hours. (C) Colony formation assay demonstrated significantly fewer colonies after FABP5 knockdown. (D) EdU assay confirmed reduced proliferative capacity in FABP5- knockdown Huh7 cells. (E) The wound assay showed the healing capability of Huh7 cells was markedly suppressed after FABP5 knockdown. (F) Western blot analysis demonstrated that FABP5 knockdown upregulated E-cadherin and downregulated N-cadherin and Vimentin.</p>
2026-09-29T20:01:47Z
Image
Figure
10.1371/journal.pone.0356359.g005
https://figshare.com/articles/figure/_p_FABP5_knockdown_suppresses_HCC_cell_proliferation_i_in_vitro_i_p_/34027509
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