2026-10-14T16:51:06Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34027506 2026-09-29T20:01:54Z category_4 category_13 category_14 category_873 category_46 category_734 category_64 portal_5 item_type_1 month_year_09_2026

<p>High FABP5 expression predicts poor prognosis and serves as an independent prognostic factor in HCC.</p> Rui An (636731) Shibing Hou (2288815) Min Hong (279203) Jiaorong Zhen (23973891) Zhijuan Wang (1900771) Haoming Huang (12791303) Weixuan Zhao (12058148) Mianmian Liao (10916520) Weiqu Yuan (23973893) Danping Huang (196661) Biochemistry Genetics Molecular Biology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer xlink "> tcga predicted worse survival independent prognostic factor experimental validation confirmed nf -&# 954 epithelial &# 8211 protein &# 8211 xlink "> fabp5 fabp5 correlated positively immune checkpoint profiles higher tide scores b &# 945 b &# 8211 b pathway genes identify potential fabp5 characterize fabp5 expression duplicate md simulations fabp5 drives pd hcc cell proliferation &# 954 tide scores b pathway therapeutic potential protein docking decreased expression cell rna promising fabp5 fabp5 shapes fabp5 regulates fabp5 knockdown vitro assays targeting compound significantly upregulated seq datasets related pathways regulatory role molecular dynamics molecular docking mesenchymal transition lipid metabolism l1 via l1 upregulation l1 axis immunosuppressive microenvironment <p>(A) Kaplan–Meier survival curves showing that high FABP5 expression is associated with reduced overall survival. (B) Kaplan–Meier survival analysis for disease-specific survival revealed significantly worse outcomes in the high FABP5 group. (C) Univariate Cox regression analysis identified FABP5 expression and TNM stage as significant prognostic factors. (D) Multivariate Cox regression confirmed FABP5 as an independent prognostic factor. (E) Prognostic nomogram integrating FABP5 expression and TNM stage to predict 1-, 3-, and 5-year survival. (F) Calibration plots showing consistency between predicted and observed survival probabilities.</p> 2026-09-29T20:01:47Z Image Figure 10.1371/journal.pone.0356359.g004 https://figshare.com/articles/figure/_p_High_FABP5_expression_predicts_poor_prognosis_and_serves_as_an_independent_prognostic_factor_in_HCC_p_/34027506 CC BY 4.0