2026-10-13T08:50:28Z
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oai:figshare.com:article/34027497
2026-09-29T20:01:51Z
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<p>FABP5 is upregulated in multiple cancers and predicts poor prognosis.</p>
Rui An (636731)
Shibing Hou (2288815)
Min Hong (279203)
Jiaorong Zhen (23973891)
Zhijuan Wang (1900771)
Haoming Huang (12791303)
Weixuan Zhao (12058148)
Mianmian Liao (10916520)
Weiqu Yuan (23973893)
Danping Huang (196661)
Biochemistry
Genetics
Molecular Biology
Chemical Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
xlink "> tcga
predicted worse survival
independent prognostic factor
experimental validation confirmed
nf -&# 954
epithelial &# 8211
protein &# 8211
xlink "> fabp5
fabp5 correlated positively
immune checkpoint profiles
higher tide scores
b &# 945
b &# 8211
b pathway genes
identify potential fabp5
characterize fabp5 expression
duplicate md simulations
fabp5 drives pd
hcc cell proliferation
&# 954
tide scores
b pathway
therapeutic potential
protein docking
decreased expression
cell rna
promising fabp5
fabp5 shapes
fabp5 regulates
fabp5 knockdown
vitro assays
targeting compound
significantly upregulated
seq datasets
related pathways
regulatory role
molecular dynamics
molecular docking
mesenchymal transition
lipid metabolism
l1 via
l1 upregulation
l1 axis
immunosuppressive microenvironment
<p>(A) Pan-cancer analysis of FABP5 expression based on TCGA datasets revealed significant differential expression across diverse tumor types. (B) FABP5 expression in HCC cell lines from the CCLE database showed heterogeneity across different lines. (C) Immunohistochemistry analysis from HPA database showing elevated FABP5 expression in HCC tissues compared with normal liver tissues. (D) Forest plot of Cox regression analyses showing FABP5 as a prognostic factor in multiple cancers. (E) FABP5 expression was significantly higher in HCC tissues compared with normal liver tissues. (F) Paired sample analysis further confirmed elevated FABP5 expression in HCC tumor tissues relative to adjacent non-tumor tissues. *<i>p</i> < 0.05, **<i>p</i> < 0.01, ***<i>p</i> < 0.001.</p>
2026-09-29T20:01:47Z
Image
Figure
10.1371/journal.pone.0356359.g001
https://figshare.com/articles/figure/_p_FABP5_is_upregulated_in_multiple_cancers_and_predicts_poor_prognosis_p_/34027497
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