2026-10-13T20:41:15Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34027438 2026-09-29T19:16:08Z category_146 category_7 category_19 category_734 category_931 category_62 category_64 portal_63 item_type_6 month_year_09_2026

Mineral–Herb Nanohybrids Generated through Endogenous Nanogenesis for Multimodal Imaging-Guided Renal Cancer Therapy Zoujun Peng (16045109) Zhangcong Yu (17941976) Jie Xing (736394) Zhen He (286179) Chen Hu (317374) Xiaolin Duan (19542281) Guiping Ren (413780) Si Chen (164760) Wenjing Pang (669776) Lingchao Xiang (1639534) Aiguo Wu (315321) Space Science Medicine Pharmacology Biological Sciences not elsewhere classified Information Systems not elsewhere classified Marine Biology Cancer tumor immune microenvironment orthotopic tumor progression inherent magnetic resonance guided cancer therapy incorporating mineral medicines corni fructus </ endogenous nanogenesis process photoacoustic imaging functions intrinsic imaging capability naturally derived biomaterials endogenous nanogenesis strategy endogenous nanogenesis derived biomaterials mineral integration magnetitum </ general strategy derived nanoparticles multimodal imaging modal imaging work expands systemic administration renal tumors recently emerged model system macrophage polarization hierarchical reassembly general applicability functional boundary favorable biocompatibility enhanced cytotoxic enable dual effective suppression coordination reconstruction cell infiltration associated ferroptotic apoptotic responses Decoction-derived nanoparticles have recently emerged as a class of naturally derived biomaterials, but their biomedical utility remains largely limited by the lack of intrinsic imaging capability. Here, we demonstrate that incorporating mineral medicines into traditional mineral–herb decoctions enables an endogenous nanogenesis process that spontaneously generates organic–inorganic nanohybrids with inherent magnetic resonance and photoacoustic imaging functions. Using <i>corni fructus</i> and <i>magnetitum</i> as a model system, we reveal that herbal ligands continuously mediate mineral dissolution, coordination reconstruction, and hierarchical reassembly through a ligand-directed dissolution–assembly mechanism, ultimately producing stable mineral–herb nanohybrids. Importantly, this endogenous nanogenesis strategy is further validated across multiple mineral–herb combinations, demonstrating its general applicability. The resulting <i>corni fructus</i>–<i>magnetitum</i> nanohybrids (N-CFM) enable dual-modal imaging of renal tumors while simultaneously inducing oxidative stress-associated ferroptotic and apoptotic responses after systemic administration. In parallel, N-CFM remodels the tumor immune microenvironment through macrophage polarization and enhanced cytotoxic T-cell infiltration, resulting in effective suppression of orthotopic tumor progression and metastasis with favorable biocompatibility. This work expands the functional boundary of decoction-derived biomaterials by introducing intrinsic imaging capability through mineral integration and provides a general strategy for developing naturally derived theranostic biomaterials for imaging-guided cancer therapy. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acsnanomed.6c00161.s001 https://figshare.com/articles/journal_contribution/Mineral_Herb_Nanohybrids_Generated_through_Endogenous_Nanogenesis_for_Multimodal_Imaging-Guided_Renal_Cancer_Therapy/34027438 CC BY-NC 4.0