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oai:figshare.com:article/34027429 2026-09-29T19:14:49Z category_7 category_12 category_14 category_16 category_19 category_62 category_64 category_132 category_134 portal_63 item_type_6 month_year_09_2026

Gigantol Ameliorates High-Fat and High-Fructose Diet-Induced Chronic Kidney Disease by Promoting TFEB-Mediated Mitophagy to Suppress Ferroptosis Yingying Song (1597639) Yurou Huang (12935195) Yaxin Huang (2078470) Yingxi Luo (20792200) Han Zhao (130768) Renwu Qin (25138702) Simeng Xiao (14331760) Cong Zhang (582922) Medicine Cell Biology Molecular Biology Physiology Pharmacology Marine Biology Cancer Infectious Diseases Virology induced cell models especially subtypes driven improving renal injury blocking mitophagy reversed edible plant dendrobium treating metabolic dysfunction gigantol alleviates metabolic related ckd driven gigantol ameliorates high metabolic dysfunction renal protection related ckd mediated mitophagy unhealthy diets suppressing ferroptosis suppress ferroptosis study demonstrates similar findings shown potential remains unclear pathological manifestations mitigating ckd gigantol suppresses gigantol represents fructose diet enhance pink1 effective strategy dietary supplementation closely correlates Chronic kidney disease (CKD) is a serious public health challenge that closely correlates with unhealthy diets. Gigantol, a naturally active compound derived from the edible plant Dendrobium, has shown potential in renal protection, but its efficacy in treating metabolic dysfunction-related CKD driven by a high-fat and high-fructose diet (HFFD) remains unclear. Here, we found that gigantol restored abnormal renal function and pathological manifestations in HFFD-fed mice. Mechanistically, gigantol suppresses the phosphorylation of TFEB at Ser211 and promotes TFEB nuclear translocation to enhance PINK1/Parkin-mediated mitophagy and suppress ferroptosis. Similar findings were observed in palmitic-acid-induced cell models. Notably, silencing TFEB or blocking mitophagy reversed the effect of gigantol on suppressing ferroptosis and improving renal injury. Overall, this study demonstrates that gigantol alleviates metabolic-dysfunction-related CKD in mice by promoting TFEB-mediated mitophagy to suppress ferroptosis, suggesting that dietary supplementation with Dendrobium or gigantol represents an effective strategy in mitigating CKD, especially subtypes driven by metabolic dysfunction. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.jafc.6c05807.s001 https://figshare.com/articles/journal_contribution/Gigantol_Ameliorates_High-Fat_and_High-Fructose_Diet-Induced_Chronic_Kidney_Disease_by_Promoting_TFEB-Mediated_Mitophagy_to_Suppress_Ferroptosis/34027429 CC BY-NC 4.0