2026-10-14T08:08:07Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34027335 2026-09-30T00:40:02Z category_30355 portal_12 item_type_5 month_year_09_2026

Yulia Korduke: APOE ε4 and Cognitive Status Moderate the Association Between Midlife Physical Activity and Cerebral Perfusion Yulia Korduke (15949823) Catherine A Morgan (25136874) Lynette J. Tippett (460309) Tracy R Melzer (25136868) Sarah Buchanan (6084716) Nick J Cutfield (25138596) Tim J. Anderson (841435) John C Dalrymple-Alford (25136864) Kiri L Brickell (25136862) Campbell J Le Heron (25136860) Ian J Kirk (25136856) Reece P. Roberts (251791) Santiago Mezzano (20777009) Erin Cawston (1190751) James P Fisher (7295144) Clinical neuropsychology mild cognitive impairment midlife physical activity arterial spin labelling cerebral perfusion APOE ε4 <p dir="ltr">Cerebrovascular dysfunction, including reduced cerebral perfusion, is increasingly recognised as an early contributor to Alzheimer's disease. Midlife physical activity (PA) is associated with lower dementia risk, and aerobic exercise trials show cerebral perfusion gains in healthy older adults, although findings in cognitively impaired groups are less consistent. Emerging evidence suggests APOE ε4 carriage may modulate these effects. We tested whether APOE ε4 carriage and cognitive status together moderated the midlife PA-cerebral perfusion association. In 174 older adults classified as cognitively unimpaired or amnestic mild cognitive impairment, midlife PA was derived from a self-reported questionnaire and cerebral blood flow (CBF) measured using pseudo-continuous ASL MRI across seven a priori ROIs. We found significant three-way interactions in the posterior cingulate, precuneus, and frontal lobe. Simple slopes demonstrated a positive PA-CBF association only in cognitively unimpaired ε4 carriers. Genetic risk and cognitive status may be important moderators of PA-CBF associations.</p> 2026-09-30T00:40:02Z Image Poster 10.17608/k6.auckland.34027335.v2 https://figshare.com/articles/poster/APOE_4_and_Cognitive_Status_Moderate_the_Association_Between_Midlife_Physical_Activity_and_Cerebral_Perfusion/34027335 CC BY 4.0