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oai:figshare.com:article/34027038 2026-09-29T17:40:33Z category_7 category_8 category_21 category_39 category_46 category_122 category_132 category_134 portal_5 item_type_1 month_year_09_2026

Detection of SUDV viral RNA in organs of IFNAR-/- mice by in situ hybridization. Michelle Gellhorn Serra (25138177) Cornelius Rohde (7356083) Lucie Sauerhering (6646112) Lars Meier (9179480) Lennart Kämper (11608114) Pauline Neubecker (23778913) Markus Eickmann (288210) Alexandra Kupke (4603690) Stephan Becker (146493) Anke-Dorothee Werner (16660476) Medicine Microbiology Biotechnology Ecology Immunology Mental Health Infectious Diseases Virology widespread systemic dissemination viral genome copies systemic viral dissemination sup >-/-< p associated immune responses post mortem </ key inflammatory features inflammatory responses described investigating filovirus pathogenesis requires preclinical evaluation pronounced inflammatory response lethal sudv infection pronounced changes preclinical studies filoviridae </ filovirus infections filovirus disease tissue pathology therapeutic antibodies tested organs sudv infection sudan virus potential limitation observed cytokine multiple cytokines medical countermeasures mechanistic basis infected controls including antivirals hematopoietic mediators following infection findings characterize encompassing pro data support chemokines compared chemokine elevations Organs were harvested after euthanization and pathologically examined post mortem. Exemplary images of liver (A-B), spleen (C-D), brain (E-F), and lungs (G-H) stained for viral genomic RNA (V-SudanEbola-NP-sense) by ISH are shown (red staining). Scale bars: Left panel 100 µm; right panel 25 µm. ISH: in situ Hybridization. 2026-09-29T17:40:18Z Image Figure 10.1371/journal.pone.0347080.g004 https://figshare.com/articles/figure/_p_Detection_of_SUDV_viral_RNA_in_organs_of_IFNAR_sup_-_-_sup_mice_by_i_in_situ_i_hybridization_p_/34027038 CC BY 4.0