2026-10-14T04:52:00Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34027035
2026-09-29T17:40:31Z
category_7
category_8
category_21
category_39
category_46
category_122
category_132
category_134
portal_5
item_type_1
month_year_09_2026
<p>Pathology of SUDV-infected IFNAR<sup>-/-</sup> mice.</p>
Michelle Gellhorn Serra (25138177)
Cornelius Rohde (7356083)
Lucie Sauerhering (6646112)
Lars Meier (9179480)
Lennart Kämper (11608114)
Pauline Neubecker (23778913)
Markus Eickmann (288210)
Alexandra Kupke (4603690)
Stephan Becker (146493)
Anke-Dorothee Werner (16660476)
Medicine
Microbiology
Biotechnology
Ecology
Immunology
Mental Health
Infectious Diseases
Virology
widespread systemic dissemination
viral genome copies
systemic viral dissemination
sup >-/-</ sup
suitable animal models
substantial weight loss
significantly elevated concentrations
div >< p
associated immune responses
post mortem </
key inflammatory features
inflammatory responses described
investigating filovirus pathogenesis
requires preclinical evaluation
pronounced inflammatory response
lethal sudv infection
pronounced changes
preclinical studies
filoviridae </
filovirus infections
filovirus disease
tissue pathology
therapeutic antibodies
tested organs
sudv infection
sudan virus
potential limitation
observed cytokine
multiple cytokines
medical countermeasures
mechanistic basis
infected controls
including antivirals
hematopoietic mediators
following infection
findings characterize
encompassing pro
data support
chemokines compared
chemokine elevations
<p>Organs were harvested after euthanization and pathologically examined <i>post mortem</i>. Exemplary images of liver <b>(A-D)</b> and spleen <b>(E-H)</b> stained with H&E are shown. In livers, multifocal liver necrosis, eosinophilic hepatocytes, lymphohistiocytic infiltrates and vacuolation were observed. In spleens, lymphoid depletion, necrotic cells as well as mononuclear infiltrates were observed. For each animal, scores for disease progression were determined (<b>I and J</b> for liver and spleen, respectively). Scale bars: A: 100 µm; B-D, G-H: 25 µm; E-F: 500 µm. <b>H&E:</b> hematoxylin and eosin; <b>n.d.:</b> no data; <b>F:</b> female; <b>M:</b> male.</p>
2026-09-29T17:40:18Z
Image
Figure
10.1371/journal.pone.0347080.g003
https://figshare.com/articles/figure/_p_Pathology_of_SUDV-infected_IFNAR_sup_-_-_sup_mice_p_/34027035
CC BY 4.0