2026-10-12T09:46:41Z
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2026-09-29T17:40:30Z
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<p>Detection of SUDV viral RNA and infectious titers in infected IFNAR<sup>-/-</sup> mice.</p>
Michelle Gellhorn Serra (25138177)
Cornelius Rohde (7356083)
Lucie Sauerhering (6646112)
Lars Meier (9179480)
Lennart Kämper (11608114)
Pauline Neubecker (23778913)
Markus Eickmann (288210)
Alexandra Kupke (4603690)
Stephan Becker (146493)
Anke-Dorothee Werner (16660476)
Medicine
Microbiology
Biotechnology
Ecology
Immunology
Mental Health
Infectious Diseases
Virology
widespread systemic dissemination
viral genome copies
systemic viral dissemination
sup >-/-</ sup
suitable animal models
substantial weight loss
significantly elevated concentrations
div >< p
associated immune responses
post mortem </
key inflammatory features
inflammatory responses described
investigating filovirus pathogenesis
requires preclinical evaluation
pronounced inflammatory response
lethal sudv infection
pronounced changes
preclinical studies
filoviridae </
filovirus infections
filovirus disease
tissue pathology
therapeutic antibodies
tested organs
sudv infection
sudan virus
potential limitation
observed cytokine
multiple cytokines
medical countermeasures
mechanistic basis
infected controls
including antivirals
hematopoietic mediators
following infection
findings characterize
encompassing pro
data support
chemokines compared
chemokine elevations
<p>Blood samples were collected on day 3 and on the day of euthanasia, together with samples of different organs. The amounts of SUDV viral RNA were measured by RT-qPCR in the organs <b>(A)</b> and serum samples <b>(B)</b> of individual mice. The qRT-PCR results are presented as original Ct values, with the y-axis inverted to facilitate interpretation. Infectious SUDV titers were determined by TCID<sub>50</sub> assay in organs <b>(C)</b> and serum samples <b>(D)</b> of individual mice. The titers present in the organs were normalised to their weight. Data are shown as mean with individual values. Dotted lines indicate the LOD (see the Methods section for details). <b>F:</b> female; <b>M:</b> male.</p>
2026-09-29T17:40:18Z
Image
Figure
10.1371/journal.pone.0347080.g002
https://figshare.com/articles/figure/_p_Detection_of_SUDV_viral_RNA_and_infectious_titers_in_infected_IFNAR_sup_-_-_sup_mice_p_/34027032
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