2026-10-11T14:46:06Z
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oai:figshare.com:article/34027029
2026-09-29T17:40:29Z
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<p>Clinical course of SUDV-infected IFNAR<sup>-/-</sup> mice.</p>
Michelle Gellhorn Serra (25138177)
Cornelius Rohde (7356083)
Lucie Sauerhering (6646112)
Lars Meier (9179480)
Lennart Kämper (11608114)
Pauline Neubecker (23778913)
Markus Eickmann (288210)
Alexandra Kupke (4603690)
Stephan Becker (146493)
Anke-Dorothee Werner (16660476)
Medicine
Microbiology
Biotechnology
Ecology
Immunology
Mental Health
Infectious Diseases
Virology
widespread systemic dissemination
viral genome copies
systemic viral dissemination
sup >-/-</ sup
suitable animal models
substantial weight loss
significantly elevated concentrations
div >< p
associated immune responses
post mortem </
key inflammatory features
inflammatory responses described
investigating filovirus pathogenesis
requires preclinical evaluation
pronounced inflammatory response
lethal sudv infection
pronounced changes
preclinical studies
filoviridae </
filovirus infections
filovirus disease
tissue pathology
therapeutic antibodies
tested organs
sudv infection
sudan virus
potential limitation
observed cytokine
multiple cytokines
medical countermeasures
mechanistic basis
infected controls
including antivirals
hematopoietic mediators
following infection
findings characterize
encompassing pro
data support
chemokines compared
chemokine elevations
<p>The experimental approach is shown in <b>(A)</b>. Female (F) and male (M) IFNAR<sup>-/-</sup> mice were infected with approx. 1,000 PFU SUDV on day 0 (n = 6) and monitored daily. The mice were euthanized at humane clinical endpoint (score of ≥10 on one day or ≥6 on two consecutive days). Blood samples were collected at day 3, and on the day of euthanasia. The additive clinical score <b>(B)</b>, summarizes the results of the different parameters analyzed daily: (C) body weight, behaviour, and appearance. Each parameter could be awarded a maximum of 10 points. Grey boxes indicate days after euthanasia. The relative body weight compared to day 0 for each mouse is depicted in <b>(D)</b>. The dotted line marks the clinical endpoint. The Kaplan-Meier survival curve <b>(E)</b> depicts the percentage of surviving mice over time.</p>
2026-09-29T17:40:18Z
Image
Figure
10.1371/journal.pone.0347080.g001
https://figshare.com/articles/figure/_p_Clinical_course_of_SUDV-infected_IFNAR_sup_-_-_sup_mice_p_/34027029
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