2026-10-13T08:00:48Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34027005 2026-09-29T17:40:17Z category_12 category_13 category_14 category_15 category_16 category_24 category_272 category_39 category_734 portal_5 item_type_1 month_year_09_2026

<p>Effect of stimulation pattern on SCN phase shift and <i>Per2</i> induction.</p> Feng Yu (273443) Ling Yang (34478) Jie Yan (119530) Cell Biology Genetics Molecular Biology Neuroscience Physiology Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified similar molecular circuitry master circadian pacemaker many peripheral tissues entrain peripheral clocks attenuated net shift scn circadian clock scn &# 8217 heat shock protein distinct temperature responses ventral scn leads overall scn phase scn network scn maintains ventral regions heat stimuli temperature variations temperature entrainment phase difference inverted phase suprachiasmatic nucleus stimulated concurrently spatial structure results suggest potential importance photic entrainment mechanisms underlying analysis reveals <p><b>A</b>: Phase response curves of the combined signal in the reduced Poincaré model for ventral-only stimulation (green) and simultaneous stimulation of both oscillators (yellow). Gray shading indicates phases where simultaneous stimulation produces a smaller phase shift than ventral-only stimulation. <b>B</b>: Representative phase-shift decompositions are shown under four conditions, corresponding from left to right to Poincaré CT9, Poincaré CT21, molecular CT18, and molecular CT4. Within each condition, solid bars represent dual stimulation and hatched bars represent ventral-only stimulation. Yellow, blue, and red bars indicate the phase shifts of the global SCN signal, dorsal, and ventral components, respectively. <b>C</b>: Net <i>Per2</i> phase shift after a 2-hour temperature pulse at CT4, as a function of pulse temperature, for three conditions: dual SCN stimulation (yellow), ventral-only stimulation (green), and homogeneous model (blue). <b>D</b>: Fold increase in <i>Per2</i> expression after stimulation under the same conditions. Fold increase was calculated as the ratio of the maximum <i>Per2</i> level after stimulation to the level immediately before stimulation.</p> 2026-09-29T18:04:40Z Image Figure 10.1371/journal.pcbi.1014831.g007 https://figshare.com/articles/figure/_p_Effect_of_stimulation_pattern_on_SCN_phase_shift_and_i_Per2_i_induction_p_/34027005 CC BY 4.0