2026-10-12T23:09:56Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026999 2026-09-29T17:40:14Z category_12 category_13 category_14 category_15 category_16 category_24 category_272 category_39 category_734 portal_5 item_type_1 month_year_09_2026

<p>Phase response of the SCN model without VIP coupling for different dorsal–ventral phase differences.</p> Feng Yu (273443) Ling Yang (34478) Jie Yan (119530) Cell Biology Genetics Molecular Biology Neuroscience Physiology Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified similar molecular circuitry master circadian pacemaker many peripheral tissues entrain peripheral clocks attenuated net shift scn circadian clock scn &# 8217 heat shock protein distinct temperature responses ventral scn leads overall scn phase scn network scn maintains ventral regions heat stimuli temperature variations temperature entrainment phase difference inverted phase suprachiasmatic nucleus stimulated concurrently spatial structure results suggest potential importance photic entrainment mechanisms underlying analysis reveals <p><b>A,B</b>: <i>Per2</i> expression and phase response after a 2-hour, 39.1°C temperature pulse at CT6.5, with a 1-hour phase difference between dorsal and ventral SCN compartments. <b>(A)</b> Upper: overall SCN <i>Per2</i> expression with and without pulse. Bottom: <i>Per2</i> in ventral and dorsal compartments. <b>(B)</b> Corresponding PRCs for overall SCN (yellow), ventral (red), and dorsal (blue); the black line indicates the pulse time. The net phase shift of the overall SCN is 2.6 hours. <b>C,D</b>: Same as <b>(A, B)</b>, but with a 4-hour dorsal–ventral phase difference. The net phase shift of the overall SCN is 1.9 hours. <b>E,F</b>: Same as above, but with an 8-hour phase difference. The net phase shift of the overall SCN is 1.1 hours. Solid and dashed lines represent simulations with and without the heat pulse. Arrows indicate measurement of phase shifts.</p> 2026-09-29T18:04:40Z Image Figure 10.1371/journal.pcbi.1014831.g005 https://figshare.com/articles/figure/_p_Phase_response_of_the_SCN_model_without_VIP_coupling_for_different_dorsal_ventral_phase_differences_p_/34026999 CC BY 4.0