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oai:figshare.com:article/34026993 2026-09-29T17:40:11Z category_12 category_13 category_14 category_15 category_16 category_24 category_272 category_39 category_734 portal_5 item_type_1 month_year_09_2026

<p>Responses of the SCN model to temperature cycles and heat pulse.</p> Feng Yu (273443) Ling Yang (34478) Jie Yan (119530) Cell Biology Genetics Molecular Biology Neuroscience Physiology Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified similar molecular circuitry master circadian pacemaker many peripheral tissues entrain peripheral clocks attenuated net shift scn circadian clock scn &# 8217 heat shock protein distinct temperature responses ventral scn leads overall scn phase scn network scn maintains ventral regions heat stimuli temperature variations temperature entrainment phase difference inverted phase suprachiasmatic nucleus stimulated concurrently spatial structure results suggest potential importance photic entrainment mechanisms underlying analysis reveals <p><b>A</b>: <i>Per2</i> rhythms (blue and red lines) do not exhibit phase reversal in response to opposite temperature schedules. The lower heatmaps are author-generated visualizations of the experimental data reported by Buhr et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014831#pcbi.1014831.ref021" target="_blank">21</a>]. <b>B</b>: <i>Per2</i> expression in the SCN model in response to a 2-hour heat pulse (38.5°C, gray shaded area) at CT12 after 12-hour low temperature (36°C). The solid and dashed lines represent the control and heat pulse conditions, respectively.</p> 2026-09-29T18:04:40Z Image Figure 10.1371/journal.pcbi.1014831.g003 https://figshare.com/articles/figure/_p_Responses_of_the_SCN_model_to_temperature_cycles_and_heat_pulse_p_/34026993 CC BY 4.0