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oai:figshare.com:article/34026992 2026-09-29T17:40:11Z category_1 category_12 category_15 category_272 category_734 category_811 category_61 category_122 portal_5 item_type_1 month_year_09_2026

<p>Consistent findings using the Schaefer 200 atlas.</p> Golia Shafiei (3191169) Joëlle Bagautdinova (25138348) Valerie J. Sydnor (25138351) Dani S. Bassett (13104131) Deanna M. Barch (6759263) Matthew Cieslak (3112521) Yong Fan (212624) Elizabeth Flook (25138354) Alexandre R. Franco (6564785) Gregory Kiar (785219) Audrey C. Luo (25138357) Michael P. Milham (8895014) Linden Parkes (6617396) Taylor Salo (5277443) Leah H. Somerville (5352008) Tien T. Tong (25138360) Russell T. Shinohara (9019436) Theodore D. Satterthwaite (11006319) Biophysics Cell Biology Neuroscience Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Developmental Biology Mental Health two independent cross spontaneous neural dynamics results reveal convergence commonly used measure hierarchical brain maturation independent developmental samples div >< p intrinsic timescale follow intrinsic timescale evolves intrinsic timescale displays highlighting intrinsic timescale human brain development sensorimotor cortex compared axis spanning sensorimotor adulthood </ p intrinsic timescale hierarchical pattern developmental patterns developmental findings association cortex n </ temporal window shorter timescales sectional datasets principled marker neuronal populations neurodevelopmental patterns major axes imaging modalities cortical organization axis ). association cortices <p>Developmental patterns of intrinsic timescale were replicated in the Schaefer 200 atlas in HCPD. <b>(a)</b> Consistent with the finding with the Schaefer 400 atlas (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3004037#pbio.3004037.g003" target="_blank">Fig 3</a>), GAM results demonstrated that average timescale increases during development in youth (partial <i>R</i>² = 0.041, <i>p</i>_anova = 9.86 × 10⁻⁷). <b>(b)</b> Region-wise GAMs identified heterogeneous age effects (i.e., partial <i>R</i>²) across the cortex. <b>(c)</b> Age effects on intrinsic timescale were hierarchically organized along the S–A axis. Significance of the association between age effects and S–A axis rank was assessed using 10,000 spin tests. <i>r</i>_s denotes Spearman’s rank correlation coefficient. Linear regression line is added for visualization purposes only. <b>(d)</b> Regional trajectories of developmental patterns in intrinsic timescale were obtained from region-wise GAM results (as shown in panel <b>b</b>). Each line corresponds to the model fit of each cortical region and is colored based on the region’s rank along the S–A axis. Similar to the findings with the Schaefer 400 atlas, the results demonstrate that intrinsic timescale in association regions increases during development in youth while it remains relatively stable in sensorimotor regions. Data and code needed to regenerate this figure can be found at <a href="https://doi.org/10.5281/zenodo.22799416" target="_blank">https://doi.org/10.5281/zenodo.22799416</a>.</p> <p>(TIFF)</p> 2026-09-29T18:01:47Z Image Figure 10.1371/journal.pbio.3004037.s005 https://figshare.com/articles/figure/_p_Consistent_findings_using_the_Schaefer_200_atlas_p_/34026992 CC BY 4.0