2026-10-10T16:14:41Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026983 2026-09-29T17:40:07Z category_1 category_12 category_15 category_272 category_734 category_811 category_61 category_122 portal_5 item_type_1 month_year_09_2026

<p>Timing of age-related differences in intrinsic timescale across two developmental cohorts.</p> Golia Shafiei (3191169) Joëlle Bagautdinova (25138348) Valerie J. Sydnor (25138351) Dani S. Bassett (13104131) Deanna M. Barch (6759263) Matthew Cieslak (3112521) Yong Fan (212624) Elizabeth Flook (25138354) Alexandre R. Franco (6564785) Gregory Kiar (785219) Audrey C. Luo (25138357) Michael P. Milham (8895014) Linden Parkes (6617396) Taylor Salo (5277443) Leah H. Somerville (5352008) Tien T. Tong (25138360) Russell T. Shinohara (9019436) Theodore D. Satterthwaite (11006319) Biophysics Cell Biology Neuroscience Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Developmental Biology Mental Health two independent cross spontaneous neural dynamics results reveal convergence commonly used measure hierarchical brain maturation independent developmental samples div >< p intrinsic timescale follow intrinsic timescale evolves intrinsic timescale displays highlighting intrinsic timescale human brain development sensorimotor cortex compared axis spanning sensorimotor adulthood </ p intrinsic timescale hierarchical pattern developmental patterns developmental findings association cortex n </ temporal window shorter timescales sectional datasets principled marker neuronal populations neurodevelopmental patterns major axes imaging modalities cortical organization axis ). association cortices <p><b>(a)</b> Derivatives of the intrinsic timescale regional developmental patterns (<b>Figs 3d</b> and <b>4d</b>) were calculated as finite differences between consecutive time points to estimate the age at which timescale development demonstrated maximal change. Specifically, the age of peak change was estimated as the age where the derivative was greatest in absolute magnitude. <b>(b)</b> To estimate the age at which age-related timescale differences were maximally aligned with the S–A axis, we calculated the first derivative of each region’s GAM smooth function for age. These derivatives represent the estimated rate of timescale differences per one-year age interval. At each age, we quantified the spatial correlation between regional derivative values and regional S–A axis ranks. To account for uncertainty in derivative estimates, we sampled 10,000 draws from the posterior derivative distribution and calculated the derivative-to-SA axis correlation for each draw. The black line shows the median correlation across draws, and the gray band shows the 95% credible interval. The pink band shows the 95% credible interval for the age of maximum alignment. Maximal alignment occurred at 14.6 years in HCPD and 12.8 years in HBN. Data and code needed to regenerate this figure can be found at <a href="https://doi.org/10.5281/zenodo.22799416" target="_blank">https://doi.org/10.5281/zenodo.22799416</a>.</p> <p>(TIFF)</p> 2026-09-29T18:01:47Z Image Figure 10.1371/journal.pbio.3004037.s002 https://figshare.com/articles/figure/_p_Timing_of_age-related_differences_in_intrinsic_timescale_across_two_developmental_cohorts_p_/34026983 CC BY 4.0