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oai:figshare.com:article/34026980 2026-09-29T17:39:13Z category_4 category_7 category_12 category_13 category_14 category_873 category_46 category_734 category_64 category_132 portal_5 item_type_3 month_year_09_2026

<p>The parameters of interaction between soluble forms of TNFSF members (used as a ligand) and Ca²⁺-loaded S100 proteins (analyte) at 25°C, as determined from the SPR data (Figs 1-3), within the heterogeneous ligand model (1), one-site binding model (2) (marked by *) or two-state model (3) (marked by **). See also Figs 4, 5; n/a, not applicable.</p> Victoria A. Rastrygina (25138459) Evgenia I. Deryusheva (7300229) Alexey S. Kazakov (6178109) Andrey S. Sokolov (25138462) Maria E. Permyakova (25138465) Ekaterina A. Litus (25138468) Vladimir N. Uversky (123421) Eugene A. Permyakov (13802061) Sergei E. Permyakov (13802058) Biochemistry Medicine Cell Biology Genetics Molecular Biology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer Infectious Diseases s100p evidences involvement equilibrium dissociation constants cellular communication mediated 4 − 1bbl comprises 20 members treat several autoimmune div >< p conserved binding sites tnfsf members tnf 13 tnfsf members tnfsf members used clinically thereby suppressing targeting signaling targeted therapy soluble forms s100 proteins s100 family potentially important pleiotropic calcium p proteins interaction partners f89 residue explored selectivity cognate receptors clinical trials cell proliferation calcium leads bone loss binding proteins adaptive immunity 24 μm 21 non 2 nm <p>The parameters of interaction between soluble forms of TNFSF members (used as a ligand) and Ca²⁺-loaded S100 proteins (analyte) at 25°C, as determined from the SPR data (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0341400#pone.0341400.g001" target="_blank">Figs 1</a>-<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0341400#pone.0341400.g003" target="_blank">3</a>), within the heterogeneous ligand model (1), one-site binding model (2) (marked by *) or two-state model (3) (marked by **). See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0341400#pone.0341400.g004" target="_blank">Figs 4</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0341400#pone.0341400.g005" target="_blank">5</a>; n/a, not applicable.</p> 2026-09-29T17:38:55Z Dataset Dataset 10.1371/journal.pone.0341400.t001 https://figshare.com/articles/dataset/_p_The_parameters_of_interaction_between_soluble_forms_of_TNFSF_members_used_as_a_ligand_and_Ca_sup_2_sup_-loaded_S100_proteins_analyte_at_25_C_as_determined_from_the_SPR_data_Figs_1-3_within_the_heterogeneous_ligand_model_1_one-site_bindin/34026980 CC BY 4.0