2026-10-13T14:26:45Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34026965
2026-09-29T17:39:07Z
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<p>The predicted contact residues (<i>orange</i>) of the TNFSF-S100 complexes mapped onto the amino acid sequences of the binding partners aligned with Clustal Omega [64].</p>
Victoria A. Rastrygina (25138459)
Evgenia I. Deryusheva (7300229)
Alexey S. Kazakov (6178109)
Andrey S. Sokolov (25138462)
Maria E. Permyakova (25138465)
Ekaterina A. Litus (25138468)
Vladimir N. Uversky (123421)
Eugene A. Permyakov (13802061)
Sergei E. Permyakov (13802058)
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Chemical Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
s100p evidences involvement
equilibrium dissociation constants
cellular communication mediated
4 − 1bbl
comprises 20 members
treat several autoimmune
div >< p
conserved binding sites
tnfsf members tnf
13 tnfsf members
tnfsf members
used clinically
thereby suppressing
targeting signaling
targeted therapy
soluble forms
s100 proteins
s100 family
potentially important
pleiotropic calcium
p proteins
interaction partners
f89 residue
explored selectivity
cognate receptors
clinical trials
cell proliferation
calcium leads
bone loss
binding proteins
adaptive immunity
24 μm
21 non
2 nm
<p>Panels <b>A</b> and <b>B</b> correspond to the aligned amino acid sequences of the S100 proteins (Ca<sup>2+</sup>-binding loops are shown in <i>yellow</i>) and TNFSF members (β-strands are labelled according to ref [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0341400#pone.0341400.ref003" target="_blank">3</a>]), respectively. The α-helices and β-strands are marked in <i>cyan</i> and <i>green</i>, respectively.</p>
2026-09-29T17:38:55Z
Image
Figure
10.1371/journal.pone.0341400.g007
https://figshare.com/articles/figure/_p_The_predicted_contact_residues_i_orange_i_of_the_TNFSF-S100_complexes_mapped_onto_the_amino_acid_sequences_of_the_binding_partners_aligned_with_Clustal_Omega_64_p_/34026965
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