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oai:figshare.com:article/34026959 2026-09-29T17:39:04Z category_4 category_7 category_12 category_13 category_14 category_873 category_46 category_734 category_64 category_132 portal_5 item_type_1 month_year_09_2026

<p>(A) Heat map of the highest affinity of soluble forms of TNFSF members for S100 proteins calculated from the SPR spectroscopy data (Table 1, Fig 4) and reported for soluble TNF/TRAIL [17,18]. The lowest ΔG value (kJ/mol) is given for each S100-cytokine interaction. (B) Correlation between the promiscuity parameter of S100 proteins [72] (columns) and number of TNFSF members specifically recogni</p> Victoria A. Rastrygina (25138459) Evgenia I. Deryusheva (7300229) Alexey S. Kazakov (6178109) Andrey S. Sokolov (25138462) Maria E. Permyakova (25138465) Ekaterina A. Litus (25138468) Vladimir N. Uversky (123421) Eugene A. Permyakov (13802061) Sergei E. Permyakov (13802058) Biochemistry Medicine Cell Biology Genetics Molecular Biology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer Infectious Diseases s100p evidences involvement equilibrium dissociation constants cellular communication mediated 4 − 1bbl comprises 20 members treat several autoimmune div >< p conserved binding sites tnfsf members tnf 13 tnfsf members tnfsf members used clinically thereby suppressing targeting signaling targeted therapy soluble forms s100 proteins s100 family potentially important pleiotropic calcium p proteins interaction partners f89 residue explored selectivity cognate receptors clinical trials cell proliferation calcium leads bone loss binding proteins adaptive immunity 24 μm 21 non 2 nm <p>The columns for “promiscuous” and “orphan” S100 proteins [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0341400#pone.0341400.ref073" target="_blank">73</a>] are colored gray and white, respectively.</p> 2026-09-29T17:38:55Z Image Figure 10.1371/journal.pone.0341400.g005 https://figshare.com/articles/figure/_p_A_Heat_map_of_the_highest_affinity_of_soluble_forms_of_TNFSF_members_for_S100_proteins_calculated_from_the_SPR_spectroscopy_data_Table_1_Fig_4_and_reported_for_soluble_TNF_TRAIL_17_18_The_lowest_G_value_kJ_mol_is_given_for_each_S100-cyto/34026959 CC BY 4.0