2026-10-14T15:38:43Z
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oai:figshare.com:article/34026790
2026-09-29T17:37:52Z
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<p>Primary outcome: Overall survival.</p>
Po-Huang Chen (8374326)
Ming-Shen Dai (835570)
Mao-Hsuan Huang (17475456)
Hsin-Yu Chen (2165956)
Li-Ting Kao (409065)
Tina Yi-Jin Hsieh (22887737)
Hong-Jie Jhou (9376258)
Cho-Hao Lee (4114723)
Medicine
Genetics
Pharmacology
Immunology
Cancer
Mental Health
showed null associations
related adverse events
propensity score matching
prior 365 days
preceding 90 days
level pattern matched
groups may differ
everyday functional ability
enhancing antitumor immunity
cd8 +&# 8201
cancer genome atlas
20 cancer types
first ici administration
008 ), driven
cannot localize slc6a4
272 tumor samples
year overall survival
target trial emulation
bzd prescription overlapping
>- value 2
134 matched patients
slc6a4 expression related
immune checkpoint blockade
users among patients
hr range 0
target trial
slc6a4 expression
immune checkpoint
tumor immune
ssri users
among 3
solid tumor
composite immune
xlink ">
versus 34
thyroid dysfunction
starting within
ssri use
ssri repurposing
ssri group
solid tumors
serotonin transporter
residual confounding
psychiatric comorbidity
primary outcome
performance status
<p><b>a</b>, Kaplan–Meier survival curves for SSRI (blue) vs. BZD (orange) cohorts with 95% CIs and number-at-risk table. HR 0.627; 95% CI [0.549, 0.716]; log-rank <i>p</i> < 0.001. <b>b</b>, Cumulative mortality at prespecified time points with absolute risk differences. The absolute difference in survival increased from 3.0% at 3 months to 14.9% at 24 months. Panel <i>b</i> values are Kaplan–Meier estimates, which account for censoring and are therefore higher than the crude proportions reported in the Abstract and <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1005262#pmed.1005262.t002" target="_blank">Table 2</a>. <i>N</i> = 1,567 propensity score-matched pairs per group.</p>
2026-09-29T18:01:32Z
Image
Figure
10.1371/journal.pmed.1005262.g003
https://figshare.com/articles/figure/_p_Primary_outcome_Overall_survival_p_/34026790
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