2026-10-10T04:46:21Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026784 2026-09-29T17:37:50Z category_7 category_13 category_19 category_46 category_64 category_122 portal_5 item_type_1 month_year_09_2026

<p>Target trial emulation study design.</p> Po-Huang Chen (8374326) Ming-Shen Dai (835570) Mao-Hsuan Huang (17475456) Hsin-Yu Chen (2165956) Li-Ting Kao (409065) Tina Yi-Jin Hsieh (22887737) Hong-Jie Jhou (9376258) Cho-Hao Lee (4114723) Medicine Genetics Pharmacology Immunology Cancer Mental Health showed null associations related adverse events propensity score matching prior 365 days preceding 90 days level pattern matched groups may differ everyday functional ability enhancing antitumor immunity cd8 +&# 8201 cancer genome atlas 20 cancer types first ici administration 008 ), driven cannot localize slc6a4 272 tumor samples year overall survival target trial emulation bzd prescription overlapping >- value 2 134 matched patients slc6a4 expression related immune checkpoint blockade users among patients hr range 0 target trial slc6a4 expression immune checkpoint tumor immune ssri users among 3 solid tumor composite immune xlink "> versus 34 thyroid dysfunction starting within ssri use ssri repurposing ssri group solid tumors serotonin transporter residual confounding psychiatric comorbidity primary outcome performance status <p>Schematic diagram of the target trial emulation framework comparing SSRI with benzodiazepine use among patients with a solid tumor and depression or anxiety who were receiving immune checkpoint inhibitors. The study timeline is divided into baseline (365 days before the index date), the index date (first ICI administration, time zero), and follow-up (days 30 to 730 after the index date, beginning at the prespecified 30-day landmark). Abbreviations: BZD, benzodiazepine; ICI, immune checkpoint inhibitor; SSRI, selective serotonin reuptake inhibitor.</p> 2026-09-29T18:01:32Z Image Figure 10.1371/journal.pmed.1005262.g001 https://figshare.com/articles/figure/_p_Target_trial_emulation_study_design_p_/34026784 CC BY 4.0