2026-10-14T15:44:39Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026712 2026-09-29T17:37:23Z category_7 category_13 category_19 category_46 category_64 category_122 portal_5 item_type_1 month_year_09_2026

<p>Serotonin-pathway genes versus immune signatures across TCGA cancers.</p> Po-Huang Chen (8374326) Ming-Shen Dai (835570) Mao-Hsuan Huang (17475456) Hsin-Yu Chen (2165956) Li-Ting Kao (409065) Tina Yi-Jin Hsieh (22887737) Hong-Jie Jhou (9376258) Cho-Hao Lee (4114723) Medicine Genetics Pharmacology Immunology Cancer Mental Health showed null associations related adverse events propensity score matching prior 365 days preceding 90 days level pattern matched groups may differ everyday functional ability enhancing antitumor immunity cd8 +&# 8201 cancer genome atlas 20 cancer types first ici administration 008 ), driven cannot localize slc6a4 272 tumor samples year overall survival target trial emulation bzd prescription overlapping >- value 2 134 matched patients slc6a4 expression related immune checkpoint blockade users among patients hr range 0 target trial slc6a4 expression immune checkpoint tumor immune ssri users among 3 solid tumor composite immune xlink "> versus 34 thyroid dysfunction starting within ssri use ssri repurposing ssri group solid tumors serotonin transporter residual confounding psychiatric comorbidity primary outcome performance status <p>Median Spearman correlation of each of 20 serotonin-pathway genes (the transporter SLC6A4, 14 serotonin receptors, the synthesis enzymes TPH1/TPH2/DDC, and the degradation enzymes MAOA/MAOB) with three immune signatures (T-cell-inflamed GEP, IFN-gamma, and cytolytic score) across 20 TCGA solid-tumor types (1,200 correlations (20 genes × 3 immune signatures × 20 cancers; pooled to 60 gene-by-signature tests in the main text); Benjamini–Hochberg corrected). SLC6A4 ranked first of 20 by pooled correlation (median rho −0.16; significant-negative in 37 of 60 gene-by-signature tests; significant-positive in only 2). The degradation enzyme MAOB correlated positively and most receptors showed weak or positive associations, indicating that the inverse association with immune signatures tracks specifically with the serotonin-handling transporter rather than the pathway at large. Blue = negative correlation; red = positive. Correlations are Spearman rank correlations; significance is assessed after Benjamini–Hochberg false discovery rate correction.</p> <p>(TIF)</p> 2026-09-29T18:01:32Z Image Figure 10.1371/journal.pmed.1005262.s009 https://figshare.com/articles/figure/_p_Serotonin-pathway_genes_versus_immune_signatures_across_TCGA_cancers_p_/34026712 CC BY 4.0