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<p>Dose response prediction of the total quantity of cAMP with internalization inhibition and with biased receptor spatial distribution for models 3.1 and 3.2 with 95% profile-based confidence intervals.</p> Chloé Weckel (25138386) Juliette Gourdon (25138389) Léo Darrigade (25138392) Vinesh Jugnarain (25138395) Pascale Crépieux (763916) Eric Reiter (7033055) Frédéric Jean-Alphonse (22090247) Stefan Haar (25138398) Romain Yvinec (25138401) Biophysics Biochemistry Cell Biology Genetics Molecular Biology Physiology Pharmacology Immunology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Cancer Mental Health Infectious Diseases throughput kinetic data often overlooked component model selection method approach thus provides theoretical gpcr models enabling systematic characterization stimulating hormone receptor induced cellular responses yet receptor trafficking induced signaling responses cellular responses receptor trafficking gpcr signaling pharmacological characterization specific receptor signaling compartmentalization initiate signaling xlink "> strong effect spatiotemporal modeling spatial organization spatial localization small fraction refined tool receptors produce methodology offers intracellular compartments including internalization growing number generalizable strategy g protein endosomal sorting endosomal dynamics critical determinants coupled receptors cell surface case study advances understanding <p>The different values of internalization are obtained by varying the parameters <i>ps</i>₂: <i>ps</i>₂ = 1, (dotted line), (dash-dot line), (dashed line), no internalization: <i>ps</i>₂ = 0 (solid line). The different values for <i>p</i>₂₃ are 0 (dotted line), 0.3 (dash-dot line), 0.7 (dashed line) and 1 (solid line), while the internalization rate remains constant for each model (, and ). Circles represent the value of <i>EC</i>₅₀. The remaining parameters used for the prediction correspond to the best estimates obtained during model selection (Table C in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014790#pcbi.1014790.s001" target="_blank">S1 Text</a>).</p> 2026-09-29T18:00:32Z Image Figure 10.1371/journal.pcbi.1014790.g010 https://figshare.com/articles/figure/_p_Dose_response_prediction_of_the_total_quantity_of_cAMP_with_internalization_inhibition_and_with_biased_receptor_spatial_distribution_for_models_3_1_and_3_2_with_95_profile-based_confidence_intervals_p_/34026711 CC BY 4.0