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<p>Impact of internalization inhibition on cAMP production using dose-response analysis.</p> Chloé Weckel (25138386) Juliette Gourdon (25138389) Léo Darrigade (25138392) Vinesh Jugnarain (25138395) Pascale Crépieux (763916) Eric Reiter (7033055) Frédéric Jean-Alphonse (22090247) Stefan Haar (25138398) Romain Yvinec (25138401) Biophysics Biochemistry Cell Biology Genetics Molecular Biology Physiology Pharmacology Immunology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Cancer Mental Health Infectious Diseases throughput kinetic data often overlooked component model selection method approach thus provides theoretical gpcr models enabling systematic characterization stimulating hormone receptor induced cellular responses yet receptor trafficking induced signaling responses cellular responses receptor trafficking gpcr signaling pharmacological characterization specific receptor signaling compartmentalization initiate signaling xlink "> strong effect spatiotemporal modeling spatial organization spatial localization small fraction refined tool receptors produce methodology offers intracellular compartments including internalization growing number generalizable strategy g protein endosomal sorting endosomal dynamics critical determinants coupled receptors cell surface case study advances understanding <p>In the different panels, the ligand (M) dose response relationship of model 1 (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014790#pcbi.1014790.g001" target="_blank">Fig 1</a>) is plotted for different values of the internalization rate: (dotted line), (dash-dot line), (dashed line), (solid line). Circles represent the <i>EC</i>₅₀ value. Common parameters to all six panels are , <i>R</i>₀ = 1, <i>k</i>^– = 1, , . The remaining parameters values (, ) are given by: <b>(A)</b> , ; <b>(B)</b> , ; <b>(C)</b> , ; <b>(D)</b> , . Parameter values were arbitrarily chosen, for illustration purposes.</p> 2026-09-29T18:00:32Z Image Figure 10.1371/journal.pcbi.1014790.g002 https://figshare.com/articles/figure/_p_Impact_of_internalization_inhibition_on_cAMP_production_using_dose-response_analysis_p_/34026684 CC BY 4.0