2026-10-11T22:36:53Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026678 2026-09-29T17:37:08Z category_1 category_4 category_12 category_13 category_14 category_16 category_19 category_46 category_734 category_811 category_64 category_122 category_132 portal_5 item_type_6 month_year_09_2026

<p>Supplementary information file.</p> Chloé Weckel (25138386) Juliette Gourdon (25138389) Léo Darrigade (25138392) Vinesh Jugnarain (25138395) Pascale Crépieux (763916) Eric Reiter (7033055) Frédéric Jean-Alphonse (22090247) Stefan Haar (25138398) Romain Yvinec (25138401) Biophysics Biochemistry Cell Biology Genetics Molecular Biology Physiology Pharmacology Immunology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Cancer Mental Health Infectious Diseases throughput kinetic data often overlooked component model selection method approach thus provides theoretical gpcr models enabling systematic characterization stimulating hormone receptor induced cellular responses yet receptor trafficking induced signaling responses cellular responses receptor trafficking gpcr signaling pharmacological characterization specific receptor signaling compartmentalization initiate signaling xlink "> strong effect spatiotemporal modeling spatial organization spatial localization small fraction refined tool receptors produce methodology offers intracellular compartments including internalization growing number generalizable strategy g protein endosomal sorting endosomal dynamics critical determinants coupled receptors cell surface case study advances understanding <p>This file presents the experimental data used in our study, the variables and parameters used in the different models, the trafficking models considered for model selection, predictions of additional results, the convergence algorithm, the profile likelihood for all parameters, the model selection results, the best-estimated parameter values, a summary of the results, and averaged outputs for the most plausible models.</p> <p>(PDF)</p> 2026-09-29T18:00:32Z Text Journal contribution 10.1371/journal.pcbi.1014790.s001 https://figshare.com/articles/journal_contribution/_p_Supplementary_information_file_p_/34026678 CC BY 4.0