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oai:figshare.com:article/34026609 2026-09-29T17:32:51Z category_4 category_8 category_12 category_13 category_14 category_272 category_46 category_734 category_106 category_132 category_134 portal_5 item_type_1 month_year_09_2026

<p>Proposed model of Sph-induced ferroptosis in mammary epithelial cells.</p> Yunfei Wei (9412265) Xinyu Zhao (102214) Ziyi Yin (4117480) Yanmin Zhang (391964) Yaxin Zhai (2562517) Baihe Zhan (25138380) Yeling Wang (371383) Jiakang He (16829817) Jianfeng Wang (232744) Xuming Deng (158166) Lei Xu (78676) Haihua Feng (198813) Biochemistry Microbiology Cell Biology Genetics Molecular Biology Environmental Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Science Policy Infectious Diseases Virology mitochondrial contact site dysregulated inflammatory response disrupt mammary tissues potential therapeutic target key virulence determinant mastitis remain elusive dependent ferroptosis contribute >- induced mastitis >- induced ferroptosis sting signaling pathway mediated mtdna release cgas ), leading staphylococcus aureus </ promote gpx4 degradation aureus </ virulence factors sting axis potential role lysosome pathway underlying mechanisms thereby eliciting sphingomyelin phosphodiesterase organizing system micos ). major pathogen diverse arsenal cyclic gmp core component amp synthase >; however <p>The figure was created entirely from scratch by the authors using Adobe Illustrator. Sph targets Mic60 and destabilizes MICOS organization, thereby disrupting mitochondrial cristae architecture and mitochondrial dynamics and promoting mtDNA release. Cytosolic mtDNA activates the cGAS-STING pathway, after which activated STING facilitates recruitment of GPX4 to LC3-associated autophagic machinery and its subsequent lysosomal degradation. Loss of GPX4 drives lipid peroxidation, and culminates in ferroptotic death of mammary epithelial cells.</p> 2026-09-29T18:02:15Z Image Figure 10.1371/journal.ppat.1014644.g008 https://figshare.com/articles/figure/_p_Proposed_model_of_Sph-induced_ferroptosis_in_mammary_epithelial_cells_p_/34026609 CC BY 4.0